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      212019 Clinicopathological features and prognosis of cystic gastrointestinal stromal tumor

      2012-08-15 00:54:32WangCuizhong王翠眾DeptGenSurgZhongshanHospFudanUnivShanghai200032ChinGastrointestSurg201114599602
      外科研究與新技術 2012年1期

      /Wang Cuizhong(王翠眾,Dept Gen Surg,Zhongshan Hosp Fudan Univ,Shanghai 200032)…∥Chin J Gastrointest Surg.-2011,14(8).-599~602

      ObjectiveTo investigate the clinicopathological and molecular genetic characteristics of gastrointestinal stromal tumor(GISTs)with significant cystic changes,and to assess their biological behavior.MethodsClinicopathological features of 7 patients with cystic GISTs treated at the Zhongshan Hospital of Fudan University from February 2005 to January 2010 were summarized retrospectively.The mutations status of c-kit and PDGFR-α were analyzed.ResultsThere were 2 males and 5 females aged from 46 to 76 years old.Primary site of GISTs included stomach(n=4),duodenum(n=1),and small intestinal(n=2).Tumor size ranged from 6 to 16 cm with obviously cystic changes.Tumor cells were found in the solid components under microscope,of which epithelioid cell type were found in 4 case and spindle cell type in 3 cases.The mitotic figures were no more than 3/50 HPF in all the patients.According to the NIH criteria,4 were high-risk and 3 were low-risk.Based on morphological characteristics,3 cases were as borderline tumor,3 moderate-risk,and 1 moderate-risk.Gene mutation of exon 11 of c-kit were identified in 3 cases.During the follow up ranging from 9 to 80 months,all the 7 patients had cancer-free survival.ConclusionThe biological behavior of cystic GIST is indolent with a low risk of malignancy and favorable prognosis.10 refs,5 figs,1 tab.

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