• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Cellular and molecular perspectives of macrophage in rheumatoid arthritis

    2017-01-16 03:42:51XinmingWANGWeiWEI

    Xin-ming WANG,Wei WEI

    (Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China)

    T1-35

    Cellular and molecular perspectives of macrophage in rheumatoid arthritis

    Xin-ming WANG,Wei WEI

    (Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China)

    Rheumatoid arthritis(RA)is a systemic,inflammatory autoimmune disease,which is still a significant unmet medical need despite significant therapeutic advances.The pathogenesis of RA involves many types of immune cells,such as T cells,B cells,macrophages and so on.It′s known that the synovial membrane contains two layers,the outer layer,or subintima and the inner layer,or intima.The intimal cells mainly include two types of cells,fibroblasts synoviocyte and macrophage-like synoviocyte.In the inflamed rheumatoid synovial tissues,there is a large number of macrophage-like synoviocytes.These cells can produce key pro-inflammatory cytokines,chemokines and growth factors and their signaling pathways,including nuclear factor κB,Janus kinase-signal transducer,are highly activated.It will trigger cartilage destruction and perpetuate inflammation.This review attempts to high?light some aberrations of macrophage in immunoreaction including the roles of genetic and environ?mental factors,cellular alterations,especially signaling pathways that are implicated in the pathogenesis of RA.

    cell;molecular;perspectives;macrophage;rheumatoid arthritis

    The project supported by National Natural Science Foundation of China(81330081,81473223 and 81673444)

    Wei WEI,Tel:13605510563,E-mail:wwei@ahmu.edu.cn

    东阳市| 万州区| 海口市| 松滋市| 堆龙德庆县| 内丘县| 哈尔滨市| 水富县| 新巴尔虎右旗| 老河口市| 翁源县| 荣昌县| 大方县| 信阳市| 横峰县| 漳浦县| 盖州市| 怀来县| 达尔| 星子县| 绍兴市| 丰顺县| 云浮市| 汶上县| 绥中县| 彭阳县| 龙陵县| 五家渠市| 佛冈县| 启东市| 镇安县| 兰考县| 定州市| 肇庆市| 河北区| 布拖县| 克山县| 承德县| 榆社县| 迁西县| 汝阳县|