俞亮++楊帆++黃佳偉
DOI:10.16662/j.cnki.1674-0742.2017.20.043
[摘要] 目的 對高壓氧聯(lián)合神經(jīng)節(jié)苷脂治療對顱腦外傷的神經(jīng)保護作用的臨床效果進行研究觀察分析。方法 方便選取該院2013年12月—2016年10月收治的92例顱腦損傷患者,根據(jù)治療方式不同分為對照組與觀察組,平均每組46例。對照組給予常規(guī)治療,觀察組給予高壓氧聯(lián)合神經(jīng)節(jié)苷脂治療治療,對比兩組臨床效果并觀察分析。結(jié)果 對照組總治愈率為28.26%,死亡率為19.57%。觀察組總治愈率為47.82%,死亡率為4.35%,兩組間數(shù)據(jù)對比差異有統(tǒng)計學意義(P<0.05)。治療前兩組患者GCS評分與Barthel指數(shù)對比差異無統(tǒng)計學意義(P>0.05),治療后觀察組GCS評分與Barthel相比較對照組均有所提升,組間比較差異有統(tǒng)計學意義(P<0.05)。結(jié)論 經(jīng)過高壓氧聯(lián)合神經(jīng)節(jié)苷脂治療對顱腦外傷的神經(jīng)保護作用效果確切,患者神經(jīng)功能恢復(fù)快,且接受度高,適用于各臨床顱腦損傷患者,值得各醫(yī)院推廣及應(yīng)用。
[關(guān)鍵詞] 高壓氧;神經(jīng)節(jié)苷脂;顱腦外傷;神經(jīng)保護作用
[中圖分類號] R5 [文獻標識碼] A [文章編號] 1674-0742(2017)07(b)-0043-03
Effect of High Pressure Oxygen and Ganglioside Treatment on the Nerve Protection of Cerebral Trauma
YU Liang, YANG Fan, HUANG Jia-wei
Department of Neurology, Leyu Town Peoples Hospital, Zhangjiagang, Jiangsu Province, 215600 China
[Abstract] Objective To research the effect of high pressure oxygen and ganglioside treatment on the nerve protection of cerebral trauma. Methods 92 cases of patients with cerebral trauma admitted and treated in our hospital from December 2013 to October 2016 were convenient selected and divided into two groups with 46 cases in each, the control group adopted the routine treatment, while the observation group were treated with high pressure oxygen and ganglioside, and the clinical effect was compared and observed. Results The differences in the total cure rate and death rate between the control group and the observation group were statistically significant(28.26%, 19.57% vs 47.82%, 4.35%)(P<0.05), before treatment, there were no obvious differences in the GCS score and Barthel index between the two groups(P>0.05), after treatment, the GCS score and Barthel index of the two groups were improved and the difference was statistically significant(P<0.05). Conclusion The effect of high pressure oxygen and ganglioside treatment on the nerve protection of cerebral trauma is definite with rapid nerve function and high acceptance, which is suitable for various patients with cerebral wounds, and it is worth promotion and application.
[Key words] High pressure oxygen; Ganglioside; Cerebral trauma; Nerve protection function
顱腦外傷是神經(jīng)外科一種常見臨床疾病,由于發(fā)病緊急,病情發(fā)展迅速,而且致殘率與致死率很高[1]。該研究方便選取該院2013年12月—2016年10月92例顱腦損傷患者,對高壓氧聯(lián)合神經(jīng)節(jié)苷脂治療對顱腦外傷的神經(jīng)保護作用的臨床效果進行研究觀察分析,現(xiàn)報道如下。
1 資料與方法
1.1 一般資料
方便選取2013年12月—2016年10月該院就診的顱腦損傷患者92例,入選標準:①入院后均影像學檢查,臨床診斷明確;②年齡在20~75歲;③格拉斯評分為5~8分[2];④經(jīng)頭顱CT和MRI檢測證實,排除心、肺、肝、腎等功能不全者,排除精神障礙患者,排除合并其他嚴重器質(zhì)性病變患者;⑤簽署治療知情同意書。隨機將92例患者分為對照組和觀察組,每組46例。對照組46例患者年齡在20~75歲,平均(47.4±11.2)歲,其中男25例,女21例;觀察組46例患者中男23例,女23例,年齡在23~72歲,平均(46.8±11.7)歲。兩組患者在一般資料上比較差異無統(tǒng)計學意義(P>0.05),有可比性。endprint