• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Systematic Review and Meta-Analysis of Fuke Qianjin Tablets(婦科千金片) in the Treatment of Chronic Pelvic In flammation

    2020-08-24 13:11:58GEXiaochen葛曉晨LVJianSUNMenghua孫夢華XIEYanming謝雁鳴SUNLinxi孫粼希ZHANGLidan張利丹
    關(guān)鍵詞:千金盆腔炎婦科

    GE Xiao-chen (葛曉晨), LV Jian (呂 健), SUN Meng-hua (孫夢華),XIE Yan-ming (謝雁鳴), SUN Lin-xi (孫粼希), ZHANG Li-dan (張利丹)

    1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China 2. Shandong University of Traditional Chinese Medicine, Jinan 250000, China

    ABSTRACT Objective:To systematically evaluate the ef ficacy and safety of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic inflammation.Methods:A systematically and comprehensively search was conducted in 4 Chinese databases of CNKI, VIP, WanFang and CBM and the foreign language databases of Pubmed, EMbase and The Cochrane Library. The retrieval time was from database establishment to March 2019. The randomized controlled trials of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic in flammation were selected according to the predetermined criteria. The quality of the included study was evaluated by Cochrane collaborative network bias risk evaluation tool, and the meta-analysis was performed by RevMan5.3 software.Results:A total of 1009 related literatures were searched. After initial screening and strict evaluation, 55 studies were included, with a total sample size of 6826 cases, including 3416 cases in the experiment group and 3410 cases in the control group. The results of meta-analysis showed that the total effective rate of Fuke Qianjin Tablets (婦科千金片) combined with antibiotics in the treatment of chronic pelvic in flammation was better than that of antibiotics alone (RR=1.20,95% CI [1.17, 1.22],P<0.00001). Fuke Qianjin Tablets (婦科千金片) combined with antibiotics was better than that of antibiotics alone in the improvement of abdominal pain symptoms (RR=1.40, 95% CI [1.04, 1.88],P<0.00001), leukorrhea abnormality (RR=1.38, 95% CI [1.16, 1.65],P<0.0004). In terms of safety, Fuke Qianjin Tablets (婦科千金片) combined with antibiotics could reduce the incidence of adverse reactions(RR=0.67, 95% CI [0.48, 0.93],P<0.02). The main adverse reactions were nausea and vomiting, bitterness and astringency in the mouth, rash and so on. All of them could be tolerated and the symptoms could disappear in the short term, and had no effect on the treatment.Conclusion:Fuke Qianjin Tablets (婦科千金片) combined with antibiotics in the treatment of chronic pelvic in flammation can improve the total effective rate, relieve abdominal pain and abnormal leukorrhea and other clinical discomfort symptoms, improve the quality of life of patients to a certain extent, and no serious adverse reactions are found. Due to the limitation of the quality and quantity of the included literature, the above conclusions need to be further studied and veri fied by high-quality research.

    KEYWORDS Fuke Qianjin Tablets (婦科千金片); Chronic pelvic inflammation; Systematic evaluation;Randomized controlled trial; Meta-analysis

    Chronic pelvic inflammatory disease, also known as chronic pelvic in flammatory disease (PID),is a group of infectious diseases mainly caused by female upper reproductive tract inflammation. PID is a common and frequently-occurring disease in gynecology. It has the characteristics of recurrent attacks and lingering dif ficulties[1]. If it is not treated in a timely, correct and active manner, in flammation will recur, and even cause tubal pregnancy, chronic pelvic pain and infertility, which will seriously affect women's physical and mental health, reduce the quality of life, and increase the economic burden on the family. Interpretation of2015 American Centers for Disease Control and Prevention's Diagnosis and Treatment of Pelvic Inflammatory Diseases[2]states that the current clinical treatments are mostly based on broad-spectrum, empirical antibiotic antiinfective treatments, covering possible pathogens of PID. Papers such asClinical Practice Guidelines for the Treatment of Common Infectious Diseases with Single/Combined Antibiotics in Traditional Chinese Medicine: Pelvic Inflammatory Diseases[3-5]pointed out that it is worth noting that the incidence of long-term sequelae is high, coupled with endlessly phenomenon of the abuse of antibiotics, prone to serious consequences such as dysbiosis, bacterial resistance, and super bacterial infection. The combination of traditional Chinese and western medicine has shown its unique advantages, which can alleviate the symptoms of discomfort and reduce the incidence of adverse reactions in a timely manner.Compared with monotherapy, it has enhanced the ef ficacy and reduced the incidence of drug resistance.In recent years, Chinese patent medicines, mainly for cooling blood and removing blood stasis and clearing heat and removing dampness, have also been widely used in the treatment of chronic pelvic in flammatory disease and have achieved good results.

    Ancient medical books did not have the name of chronic pelvic inflammatory disease. According to their clinical characteristics, it can be classified as diseases such as "leukorrheal diseases","abdominal pain in women", "hot into the blood chamber" and so on. Traditional Chinese medicine(TCM) considers damp, heat, and toxin to be the key etiologies of chronic pelvic in flammatory diseases[6],so antipyretic and analgesic, antibacterial and antiinflammatory are taken as treatment principles.Chinese patent medicine Fuke Qianjin Tablets (婦科千金片) uses Qian Jin Ba (Flemingia philippinensis),Chuan Xin Lian (Herba Andrographis), Jin Ying Gen (Rosa Laevigata Radix) and other drugs as sovereign medicine, and Ji Xue Teng (Caulis Spatholobi) is minister medicine. The medicine instruction indicates that it has the functions of clearing heat and removing dampness, nourishing qi and resolving blood stasis, and is mainly used to treat discomfortable symptoms of chronic pelvic in flammatory disease, endometritis, chronic cervicitis and other diseases caused by dampness heat and blood stasis stagnation[7,8]. In clinical application and literature reports, they are basically consistent with the indications in the manual.

    At present, there are still few relevant systematic reviews at home and abroad. 3 systematic reviews/meta-analysis[9-11]of Fuke Qianjin Tablets (婦科千金片) for chronic pelvic inflammatory disease were published after retrival. Through full-text analysis, these studies have certain limitations and deficiencies, mainly reflected in: ① the intervention measures were not uniform; ② the quality of the included literature wa uneven; ③ the inclusion and exclusion criteria were "complementary", which leaded to inaccurate research conclusions; ④ no subgroup analysis for different studies of specific antibiotic drugs or combined analysis after indicating clinical rationality, and the research results obtained are questioned; ⑤ different retrieval methods and methods leaded to incomplete retrieval and inaccurate research results; ⑥ the outcome evaluation indicator was single or did not analyze the included outcome indicators, and the authenticity of the research results were in doubt; ⑦ the time between retrival to publishing was too long, and the data was not updated in time. On the basis of reflecting the limitations and deficiencies in the above studies, this study comprehensively and systematically collected published or unpublished related studies, updated relevant clinical data in a timely manner, and used rigorous evaluation methods to screen out documents that met quality standards.Qualitative or quantitative analysis are performed to further systematically evaluate the effectiveness and safety of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic in flammatory disease, and provide more reliable evidence-based evidence.

    MATERIALS AND METHODS

    Screening Criteria

    Design type: randomized controlled trials(RCTs) of Fuke Qianjin Tablets (婦科千金片) for chronic pelvic inflammatory disease, regardless of language and publication restrictions. Research subjects: Regardless of whether the diagnostic criteria for chronic pelvic inflammatory disease are described in detail in the literature, they can be included as long as they are described as being diagnosed with chronic pelvic in flammatory disease or chronic pelvic in flammatory disease. Intervention measures: The experiment group was Fuke Qianjin Tablets (婦科千金片) or combined with Fuke Qianjin Tablets (婦科千金片) on the basis of the control group; the control group was conventional treatment or antibiotics without Fuke Qianjin Tablets(婦科千金片). Antibiotics such as moxifloxacin,levofloxacin, metronidazole, ceftriaxone sodium,penicillin, and amoxicillin and clavulanate potassium are the main antibiotics. Conventional treatments include antibiotics, nutritional support, vitamins and corrective electrolyte disorders. The main outcome indicators: the effectiveness of improving the clinical symptoms of chronic pelvic in flammatory disease (cured, marked effective, and effective are considered effective), and the secondary outcome indicators: improvement of abdominal pain, normal time of leucorrhea, and adverse reactions.

    For the literatures with serious errors in the research data, full text cannot be obtained,animal experimental research, non-randomized controlled trial literature, other Chinese herbs in the intervention measures (such as Chinese patent medicines, Chinese materia medica extract injections, decoctions), acupuncture, auricular points, Chinese medicine enemas, etc. as a means of adjuvant therapy were excluded. The data with duplicate data retains the most complete one.

    Retrieval Strategy

    Computer search of 4 Chinese databases of Chinese National Knowledge Infrastructure (CNKI),Chinese Science and Technology Periodical Database (VIP), Wangfang Data, China Biomedical Database (CBM), and foreign language database of PubMed, EMbase, The Cochrane Library.The retrieval time was from the time of database establishment to March 2019. The Chinese search terms were "婦科千金片", "千金片", "慢性盆腔炎", "慢性盆腔炎性疾病". The English database search was mainly based on the subject words combined with free words. The search terms were "Gynecologic Qianjin tablets", "Qianjin tablets", and "chronic pelvic inflammatory disease". In addition, grey literatures such as conference papers, dissertations, etc. were also searched.

    Literature Screening and Data Extraction

    A total of 2 researchers independently screened the literature and cross-checked the extracted data according to the developed screening criteria. In case of disagreement, it was discussed or decided by a third researcher. First of all, the initial screening was performed based on the titles and abstracts of the obtained documents. After excluding documents that obviously do not meet the inclusion criteria,further reading was performed on the full text of the documents that may meet the inclusion criteria and rescreening to determine whether to include them.The data were extracted using Excel to establish a data extraction table. The main items included investigator, study type, patient age, number of patients in the experimental group and the control group, interventions and outcome indicators of the 2 groups.

    Processing of Multi-Arm Experiments

    When the study has one or more common intervention groups, the methods recommended in the Cochrane Handbook were selected: group and merge to convert a multi-arm trial to a two-arm trial.

    Methodological Quality Evaluation of Included Literature

    A total of 2 researchers independently evaluated the methodological quality of the literature and discussed and resolved if disagreement occurred.The Cochrane collaborative network bias risk tools was used to evaluate the quality of the literature,including random sequence generation, allocation hiding, double-blind implementation and subject,blinding the outcome evaluator, incomplete result data, selective reporting, and other 7 entries for bias(eg, potential bias associated with a particular study design, statement of fraud, etc.). Finally, a total of 3 judgments of "low risk of bias", "high risk of bias", and"uncertain risk of bias" were made to the literatures.

    Statistical Analysis

    Statistical analysis was performed using RevMan5.3 software provided by the Cochrane collaboration network. Relative risk (RR) was selected for enumeration data or binary variables to represent the merge result. When the measurement data or continuous variables used the same unit of measurement, the mean difference (MD) is used, and expressed with effect size and 95%confidence interval (CI). The clinical and statistical heterogeneity between studies were determined.Clinical heterogeneity was determined based on the similarity of the research objects, interventions,controls, and outcome indicators between studies;statistical heterogeneity was measured using the Cochrane Q test, and its size was evaluated usingI2: ifP>0.1 andI250%, it is considered that the statistical homogeneity is good, and a fixed effect model is used. IfP0.1 andI2>50%, it indicates that statistical heterogeneity is large. A random effect model is used to perform sensitivity analysis or subgroup analysis to determine the homogeneity reasons. If the study does not meet the requirements of the meta-analysis, a descriptive analysis was performed. If there were10 articles included in an outcome indicator, a funnel plot was drawn to determine the publication bias of the included study.

    Figure 1. Literature Screening Process

    RESULTS

    Literature Search

    A total of 1009 related papers were initially retrieved and imported into the document management software NoteExpress. The remaining 422 papers were performed duplicate checking.After reading the titles and abstracts, 89 papers were initially selected for full-text evaluation. After further reading the full-text, 55 papers were finally included, which were all written in Chinese. The literature screening process was shown in Figure 1.

    Basic Characteristics of Included Studies

    A total of 55 studies were included, including 56 trials. One of the studies[12]was a multi-arm trial(that is, it contained multiple interventions). There was a common intervention group, which was grouped into two-arm trials. The effect size was calculated by the method in the Cochrane manual.Except for a the total sample size was 6,826, the maximum sample size was 1,175, and the minimum sample size was 48. There were 3416 cases in the experimental group, and 3410 cases in the control group. The speci fic content was shown in Tables 1 and Table 2.

    Quality Evaluation of Included Studies

    None of the 55 studies reported research protocols, sample size estimates, and follow-up. 9 studies[14,15,17-19,21,30,33,43]reported using a random number table method, 2 studies[22,45]used a random order of visiting or admission, and 1 study[26]used the method of random color ball extraction, the rest of the studies did not report speci fic random implementation plan, only mention random. 9 studies[14,21,22,27,34,35,41,43,60]reported that all patients signed the informed consent.No study mentioned the use of blindness and the concealment of reporting random allocation schemes.No study did not fully report pre-speci fied indicators,and there was no case of selective reporting of results. Bias risk assessments included in the study were shown in Figure 2 and risk assessments were shown in Table 3.

    Table 1. Basic Information Included in the Study

    (Continued)

    (Continued)

    Meta-Analysis

    Total effective rate

    Clindamycin + Fuke Qianjin Tablets (婦科千金片) VS Clindamycin Clindamycin + Fuke Qianjin

    Tablets (婦科千金片) VS Clindamycin were included in 15 studies[13,16,26,34,48,49,51,52,54,55,57-59,64,66]. Metaanalysis results showed that the heterogeneity test showed that the heterogeneity was small (P=0.68,I2=0%), so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片)group was signi ficantly improved (RR = 1.20, 95% CI[1.16, 1.26],P<0.00001), as shown in Figure 3.

    Table 2. Characteristics of Multi-Arm Test

    Figure 2. Percentage of Items Included in the Study with Risk of Bias

    Penicillin + Fuke Qianjin Tablets (婦科千金片) VS Penicillin Penicillin + Fuke Qianjin Tablets(婦科千金片) VS Penicillin was included in 5 studies[12,27,44,45,56]. Meta-analysis results showed that heterogeneity test showed less heterogeneity(P=0.74,I2=0%), so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片) group was signi ficantly improved (RR = 1.16,95% CI [1.08, 1.26],P<0.0001), as shown in Figure 4.

    Amoxicillin + Fuke Qianjin Tablets (婦科千金片)VS Amoxicillin Amoxicillin + Fuke Qianjin Tablets(婦科千金片) VS Amoxicillin included 1 study[43].Due to the small sample size, a descriptive analysis was performed. The raw data were analyzed by RevMan software to get the correspondingPvalue,so as to determine whether the study had statistical differences. In this study, the control group was amoxicillin, and the experiment group was Fuke Qianjin Tablets (婦科千金片) + amoxicillin. The results showed no signi ficant statistical signi ficance (P=0.05).The total effective rate in the observation group was 93.33%, and the total effective rate in the control group It was 73.33%, indicating that the efficacy of Fuke Qianjin Tablets (婦科千金片) + amoxicillin may be better than that of amoxicillin. However, because the number of descriptive analyses is small, the results obtained do not provide sufficient clinical evidence, so they are only for clinical reference.

    Antibiotics + Fuke Qianjin Tablets (婦科千金片)VS Antibiotics Antibiotics + Fuke Qianjin Tablets (婦科千金片) VS Antibiotics included in 2 studies[36,65].Meta-analysis results showed that the heterogeneity test showed less heterogeneity (P=0.50,I2=0%),so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片) group was signi ficantly improved (RR = 1.33, 95% CI [1.16,1.54],P<0.0001 ), as shown in Figure 5.

    Routine Therapy + Fuke Qianjin Tablets (婦科千金片) VS Routine Therapy Routine Therapy+ Fuke Qianjin Tablets (婦科千金片) VS Routine Therapy included 2 studies[41,47], and the metaanalysis results showed that heterogeneity test showed less heterogeneity (P=0.89,I2=0%), so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片) group was significantly improved (RR = 1.32, 95% CI [1.15,1.52] ,P<0.0001), as shown in Figure 6.

    Levofloxacin + Metronidazole + Fuke Qianjin Tablets (婦科千金片) VS Lefloxacin + Metronidazole Levo floxacin + Metronidazole + Fuke Qianjin Tablets(婦科千金片) VS Levofloxacin + Metronidazole included in 24 studies[14,15,20,21,23-25,28-30,32,33,37-39,40,42,50,51,53,60-63]. Meta-analysis results showed that heterogeneity test showed less heterogeneity

    (P=0.23,I2=16%), so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片)group was signi ficantly improved (RR = 1.22, 95% CI[1.19, 1.26],P<0.00001), as shown in Figure 7.

    Table 3. Risk Assessment Form

    (Continued)

    Figure 3. Total Effective Rate: Clindamycin + Fuke Qianjin Tablets (婦科千金片) VS Clindamycin Oral Administration/ Intravenous Drip

    Figure 4. Total Effective Rate: Penicillin + Fuke Qianjin Tablets (婦科千金片) VS Penicillin Intravenous Drip

    Figure 5. Total Effective Rate: Antibiotic + Fuke Qianjin Tablets (婦科千金片) VS antibiotic intravenous drip

    Figure 6. Total Effective Rate: Routine Therapy + Fuke Qianjin Tablets (婦科千金片) VS Routine Therapy

    Figure 7. Total Effective Rate: Levo floxacin + Metronidazole + Fuke Qianjin Tablets (婦科千金片) VS Le floxacin + Metronidazole

    Levofloxacin + Fuke Qianjin Tablets (婦科千金片) VS Levofloxacin Levofloxacin + Fuke Qianjin Tablets (婦科千金片) VS Levofloxacin included in 4 studies[17-19,31]. Meta-analysis results showed that the heterogeneity test showed less heterogeneity (P=0.96,I2=0%), so the fixed effect model was used to combine the effect size. Meta-analysis results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片) group was signi ficantly improved (RR = 1.28, 95% CI [1.13,1.45],P<0.00001), as shown in Figure 8.

    Improvement of abdominal pain

    3 studies[13,41,46]reported the improvement of abdominal pain. After heterogeneity test, the heterogeneity among the studies was obvious(I2=71%), so the random effect model was used(RR = 1.40, 95% CI [1.04, 1.88],P=0.03). The analysis found no statistical difference between the 3 studies, as shown in Figure 9. After reading the original literature, it was found that the average course of disease had obvious differences between 1 study[41]and others 2 studies[13,46], which may be the main reason for the large heterogeneity. After excluding this study and re-analyzing the other 2 studies, the heterogeneity was signi ficantly reduced(P=0.26,I2=20%), so a fixed effect model was used.The results showed that the differences between the 2 groups were statistically significant (RR = 1.62,95% CI [1.27, 2.05],P<0.0001).

    Normal Time of Leucorrhea

    2 studies[13,46]reported improvements in leucorrhea. Heterogeneity tests showed less heterogeneity (P=0.87,I2=0%), so a fixed effect model was used for meta-analysis. The results showed that compared with the control group, the total effective rate of the Fuke Qianjin Tablets (婦科千金片) group was significantly improved and the difference was statistically significant (RR = 1.38, 95% CI [1.16,1.65],P=0.0004), as shown in Figure 10.

    Figure 8. Total Effective Rate: Levo floxacin + Fuke Qianjin Tablets (婦科千金片) VS Levo floxacin

    Figure 9. Forest Plot of Abdominal Pain Improvement

    Figure 10. Forest Plot of Normal Time of Leukorrhea

    Adverse Reactions

    A total of 24 studies[12,15,16,23,24,26-28,30,33,34,37,38,41-43,

    47-49,51,59,61,64,66]reported the occurrence of adverse reactions, of which 22 studies[12,15,16,23,24,26,28,30,33,34,37,38,41-43,47-49,51,59,61,66]occurred adverse reactions and were all relieved after discontinuation of the drug. No obvious adverse reactions were seen in the 2 studies.The speci fic conditions were shown in Table 4.

    Table 4. Summary of Adverse Reactions

    Publishing Bias

    A publication bias analysis was performed on the total effective rate and adverse reactions of the 2 subgroups with the number of studies10, as shown in Figures 11 and Figure 12. As can be seen from the funnel plot, the asymmetry of the studies on both sides indicated that there may be potential publication bias, and the reasons for the publication bias were diverse. It may be that the negative results were not published, and some of the literature was of low quality and few samples included. The analysis studies were all in Chinese, so there may be factors such as language publishing bias.

    (Continued)

    Figure 11. Funnel Plot of Total Effective Rate

    DISCUSSION

    Effectiveness of Fuke Qianjin Tablets (婦科千金片) in the Treatment of Chronic Pelvic In flammatory Disease

    This study used rigorous inclusion and exclusion criteria to finally screen out 55 studies,which systematically evaluated the effectiveness of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic in flammatory disease from the total effective rate, improvement of abdominal pain, and normal time of leucorrhea. For analyzing the total effective rate, the study performed subgroup analysis based on different interventions; For relieving clinical symptoms (abdominal pain, leucorrhea abnormalities), qualitative analysis was used. The results showed that in the case of consistent ef ficacy standards, Fuke Qianjin Tablets (婦科千金片)combined with antibiotics (clindamycin phosphate tablets, penicillin, levo floxacin, metronidazole, etc.)were better than antibiotics alone in the treatment of chronic pelvic inflammation. On the basis of conventional treatment, the efficacy of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic in flammatory disease combined with antibiotics was also better than that of antibiotics alone. It also has obvious advantages in the relief of abdominal pain and leucorrhea, which can effectively relieve the clinical signs and symptoms of patients with chronic pelvic in flammatory disease.

    Figure 12. Funnel Plot of Adverse Reaction Rate

    Safety of Fuke Qianjin Tablets (婦科千金片) in the Treatment of Chronic Pelvic In flammatory Disease

    This study mainly systematically evaluated the safety of Fuke Qianjin Tablets (婦科千金片)in the treatment of chronic pelvic inflammation from the occurrence of adverse reactions. Metaanalysis results showed that the incidence of adverse reactions of Fuke Qianjin Tablets (婦科千金片) combined with antibiotics in chronic pelvic inflammation was significantly lower than that of antibiotics alone. It showed that the treatment of chronic pelvic inflammatory disease with Fuke Qianjin Tablets (婦科千金片) combined with antibiotics can not only play a synergistic effect, but also reduce the incidence of adverse reactions.

    A total of 24 studies in this study reported adverse reactions after medication, of which 2 studies reported no adverse reactions in both groups, and 22 studies reported adverse reactions in the experiment group or the control group. Most of the symptoms were gastrointestinal discomfort,headache, dizziness, and rash, which did not affect the normal treatment. The patients could relieve themselves after stopping the drug without serious adverse reactions. Due to the combination of drugs, incomplete research information, and low methodological quality, its safety needs further research and clarification. This study recommends the standardized use of Fuke Qianjin Tablets (婦科千金片) for clinical monitoring and standardized records, and the combined use of drugs should be avoided as much as possible to reduce the risk of adverse drug reactions.

    Methodological Quality of the Study

    There were differences in the speci fic content of western medicine treatment among the studies included, which may lead to heterogeneity and affect the research results. For different interventions included in the study, subgroup analysis was performed, which reduced the heterogeneity between studies to a certain extent and improved the accuracy of the results.

    From the randomized controlled trials of Fuke Qianjin Tablets (婦科千金片) for chronic pelvic inflammation included in this study, the limitations are mainly as follows: ① A total of 53 studies mentioned the random method, of which 9 studies showed that the random number table method was adopted. None of the studies mentioned the blind method and allocation concealment, and it was impossible to determine whether the random and blind methods were truly implemented, and it was prone to bias issues. ② All studies did not report lost follow-up; ③ No studies reported long-term followup. Chronic pelvic inflammatory disease is difficult to heal. Long-term follow-up are needed, but all the included literatures did not peform follow-up, so it is impossible to determine the long-term efficacy; ④Only 28 studied had sample size100 cases, 14 sample size70. Due to small sample size, some studies may result in unstable efficacy indicators and low test ef ficacy. ⑤ A total of 7 reports showed that patients have signed informed consent. ⑥ The total effective funnel chart showed an asymmetric distribution, which indicated that there was a publication bias. Subjective bias exaggerated the improvement of the experiment group on chronic pelvic in flammatory disease.

    Compared with the previously published 3 systematic reviews/meta-analysis results of Fuke Qianjin Tablets (婦科千金片) for the treatment of chronic pelvic inflammatory disease, the results of this study are roughly the same in terms of total treatment effectiveness, but there are many limitations and shortcomings in the previous systematic review, of which the intervention measures (Fuke Qianjin Capsules (婦科千金膠囊)or Fuke Qianjin Tablets (婦科千金片)) of 1 study[10]were not unified. The intervention measures are too complicated, and there are large differences between studies, which cannot accurately reflect the effect of Fuke Qianjin Tablets (婦科千金片)on chronic pelvic inflammation; The intervention measures of 1 study[11]included applied 2 Chinese patent medicines at the same time, which led to inaccurate research conclusions, and the publication time was too long, and the data urgently needed to be updated. 1 study[9]was not comprehensively searched and only included 12 papers. The total sample size was small and the quality was low.The latest literature search of the above 3 articles was up to February 2017, and this study has been searched until March 2019, and 19 new studies that meet the criteria after February 2017 have been newly selected. At the same time, in order to avoid incomplete search, this study has developed a strict and comprehensive search strategy. The included studies used uni fied intervention measures to expand the search scope. A total of 55 studies were included in the study, with a total sample size of 6826 cases. The research results are more accurate, more representative, and extensive. This study more systematically and comprehensively evaluated the effectiveness and safety of Fuke Qianjin Tablets (婦科千金片) in the treatment of chronic pelvic in flammatory disease from the total effective rate, the relief of abdominal pain, the normal time of leucorrhea and the occurrence of adverse reactions, providing newer, more comprehensive and accurate information and evidence-based evidence for clinical practice.

    Clinical Guidance Signi ficance

    Based on the results of this study, Fuke Qianjin Tablets (婦科千金片) combined with antibiotics has a significant effect on chronic pelvic inflammatory disease, which can increase the total effectiveness and improve clinical symptoms and signs. In terms of total effectiveness, analysis showed that the results of the Fuke Qianjin Tablets (婦科千金片)combined with antibiotics are signi ficantly better than the antibiotic single-use group, which suggests that in clinical practice for patients with chronic pelvic inflammatory disease, we can consider adding Fuke Qianjin Tablets (婦科千金片) on the basis of antibiotics to improve the efficacy and reduce the incidence of adverse reactions. The use of Fuke Qianjin Tablets (婦科千金片) can help reduce the use of antibiotics, and can reduce the incidence of antibiotic abuse and antibiotic resistance to some extent. In view of the low overall quality of this included study, the results of the study need to be further confirmed, so clinicians need to take into account the actual situation of patients, carefully refer to the results of this study, follow treatment guidelines and combine clinical experience to integrate all aspects of social-physical-psychological conditions. Based on comprehensive consideration,this can guide clinical practice.

    CONCLUSION

    To sum up, based on the existing research data, evidence and methods, Fuke Qianjin Tablets(婦科千金片) combined with antibiotics or Fuke Qianjin Tablets (婦科千金片) can significantly improve the clinical efficacy in the treatment of chronic pelvic inflammatory disease, and can improve the discomfort such as abdominal pain and leucorrhea to a certain extent, improve the quality of life of patients, and have not found serious adverse reactions. However, because the methodological quality of the included studies is not high, and some of the evidence is of low grade, it is recommended to conduct long-term follow-up in future studies and carry out large-scale, multi-center randomized double-blind controlled trials to further verify the effectiveness and safety of Fuke Qianjin Tablets(婦科千金片) in the treatment of chronic pelvic in flammation, especially long-term ef ficacy, improve the quality of evidence.

    猜你喜歡
    千金盆腔炎婦科
    Effects of Fuke Qianjin Formula on hormones and their receptors and metabonomics study in uterine fibroids model rats
    “千金”原來指男兒身
    秒懂婦科體檢報告 這個可以有!
    好日子(2018年9期)2018-10-12 09:57:28
    中西醫(yī)結(jié)合治療慢性盆腔炎的療效觀察
    婦科手術(shù)后常見問題解答
    媽媽寶寶(2017年3期)2017-02-21 01:22:34
    千金碎夢
    千金醉琴
    中西醫(yī)結(jié)合治療慢性盆腔炎30例
    中西醫(yī)結(jié)合治療慢性盆腔炎48例
    中西醫(yī)結(jié)合治療慢性盆腔炎的觀察與護理
    国产一区亚洲一区在线观看| 久久国内精品自在自线图片| 国产乱来视频区| 99热这里只有是精品50| 日本免费在线观看一区| 亚洲怡红院男人天堂| 嫩草影院新地址| 性色avwww在线观看| 成年免费大片在线观看| 久久亚洲国产成人精品v| 午夜福利网站1000一区二区三区| 亚洲18禁久久av| 亚洲婷婷狠狠爱综合网| 亚洲美女搞黄在线观看| 老司机影院毛片| av国产免费在线观看| 日本猛色少妇xxxxx猛交久久| 久久久久九九精品影院| 国产综合懂色| 大话2 男鬼变身卡| 有码 亚洲区| 亚洲四区av| 午夜精品国产一区二区电影 | 嫩草影院入口| 国产在线一区二区三区精 | 亚洲最大成人av| 久久久国产成人免费| 国产亚洲av片在线观看秒播厂 | 国产成人精品久久久久久| 日韩制服骚丝袜av| 性插视频无遮挡在线免费观看| 蜜桃亚洲精品一区二区三区| 国产精品一区二区三区四区免费观看| 久久这里只有精品中国| 一级毛片我不卡| 久99久视频精品免费| 极品教师在线视频| 欧美高清成人免费视频www| 国产探花极品一区二区| av国产免费在线观看| 日本av手机在线免费观看| 日韩一区二区三区影片| 人人妻人人看人人澡| 欧美精品一区二区大全| 综合色av麻豆| 三级毛片av免费| av专区在线播放| 国产免费一级a男人的天堂| 亚州av有码| 男插女下体视频免费在线播放| 国产精品永久免费网站| 欧美激情久久久久久爽电影| 亚洲精品日韩av片在线观看| 日韩av在线大香蕉| 乱码一卡2卡4卡精品| 欧美最新免费一区二区三区| 色吧在线观看| 一本一本综合久久| 国产成人精品一,二区| 全区人妻精品视频| 亚洲av成人av| 国产麻豆成人av免费视频| 国产探花在线观看一区二区| 亚洲av中文av极速乱| 精品久久国产蜜桃| 亚洲国产精品成人久久小说| 日韩在线高清观看一区二区三区| 美女大奶头视频| 在线观看美女被高潮喷水网站| 国产乱来视频区| 国产伦一二天堂av在线观看| 精品人妻视频免费看| 我要搜黄色片| 精品人妻一区二区三区麻豆| 午夜福利网站1000一区二区三区| 噜噜噜噜噜久久久久久91| 韩国av在线不卡| 免费av观看视频| 汤姆久久久久久久影院中文字幕 | 18禁在线无遮挡免费观看视频| 亚洲久久久久久中文字幕| 少妇高潮的动态图| 九九久久精品国产亚洲av麻豆| 性插视频无遮挡在线免费观看| 高清在线视频一区二区三区 | av在线播放精品| 欧美成人免费av一区二区三区| 少妇熟女aⅴ在线视频| 日本午夜av视频| 99久久无色码亚洲精品果冻| 国产色爽女视频免费观看| 国产午夜福利久久久久久| 亚洲国产欧美在线一区| 三级毛片av免费| av在线亚洲专区| 精品人妻视频免费看| 日日摸夜夜添夜夜爱| 成人亚洲精品av一区二区| 少妇高潮的动态图| 五月玫瑰六月丁香| 国产中年淑女户外野战色| 在线播放无遮挡| 中文欧美无线码| 久久精品久久精品一区二区三区| 午夜久久久久精精品| 亚洲国产高清在线一区二区三| 黑人高潮一二区| 男人和女人高潮做爰伦理| 日韩欧美国产在线观看| 内射极品少妇av片p| 国产av码专区亚洲av| 麻豆av噜噜一区二区三区| 99久久精品国产国产毛片| 国产精品永久免费网站| 国产精品国产高清国产av| 国产日韩欧美在线精品| a级一级毛片免费在线观看| 在线观看66精品国产| 99视频精品全部免费 在线| 久久久午夜欧美精品| 2022亚洲国产成人精品| 久久久久精品久久久久真实原创| 免费观看人在逋| 三级毛片av免费| 国产成人午夜福利电影在线观看| 成年版毛片免费区| 精品熟女少妇av免费看| 菩萨蛮人人尽说江南好唐韦庄 | 69人妻影院| 久久精品国产鲁丝片午夜精品| 欧美日韩综合久久久久久| 日韩三级伦理在线观看| 韩国高清视频一区二区三区| 伦理电影大哥的女人| 久久久久久伊人网av| 2021少妇久久久久久久久久久| 成人一区二区视频在线观看| av国产免费在线观看| 日韩高清综合在线| 日韩在线高清观看一区二区三区| 日日撸夜夜添| 免费看av在线观看网站| 国产av码专区亚洲av| 有码 亚洲区| 干丝袜人妻中文字幕| 免费无遮挡裸体视频| 我的女老师完整版在线观看| 啦啦啦啦在线视频资源| 成年女人看的毛片在线观看| 偷拍熟女少妇极品色| 国产久久久一区二区三区| 插逼视频在线观看| 日韩强制内射视频| 别揉我奶头 嗯啊视频| 国产午夜福利久久久久久| 国产精品爽爽va在线观看网站| 亚洲av不卡在线观看| 亚洲色图av天堂| 免费不卡的大黄色大毛片视频在线观看 | 亚洲精品日韩在线中文字幕| 男女边吃奶边做爰视频| 在线免费观看不下载黄p国产| 国产探花极品一区二区| 国产一区亚洲一区在线观看| 女的被弄到高潮叫床怎么办| 纵有疾风起免费观看全集完整版 | 精品久久久久久久末码| 久久久久久久久中文| 色噜噜av男人的天堂激情| 午夜精品在线福利| 色综合色国产| 精品久久久久久久久av| 九九爱精品视频在线观看| 国产精品一区二区在线观看99 | 精品免费久久久久久久清纯| 欧美潮喷喷水| 搡女人真爽免费视频火全软件| 亚洲四区av| 色5月婷婷丁香| 国产成人91sexporn| 简卡轻食公司| 黄色日韩在线| 青春草亚洲视频在线观看| 成年av动漫网址| 国产av码专区亚洲av| 国产亚洲最大av| 亚洲国产成人一精品久久久| 久久久久久九九精品二区国产| 日日干狠狠操夜夜爽| 国产色爽女视频免费观看| 国产亚洲5aaaaa淫片| 美女内射精品一级片tv| 日日摸夜夜添夜夜添av毛片| 久久久久久久久久黄片| 欧美成人精品欧美一级黄| 欧美日韩一区二区视频在线观看视频在线 | 国产伦一二天堂av在线观看| 一边亲一边摸免费视频| 精品人妻一区二区三区麻豆| 日本午夜av视频| 在现免费观看毛片| 国产精品.久久久| av又黄又爽大尺度在线免费看 | 成人毛片60女人毛片免费| 国产精品精品国产色婷婷| 一卡2卡三卡四卡精品乱码亚洲| 色网站视频免费| 九九热线精品视视频播放| 亚洲久久久久久中文字幕| 欧美一区二区精品小视频在线| 一夜夜www| 国产色婷婷99| 搡女人真爽免费视频火全软件| 日韩 亚洲 欧美在线| 一个人看的www免费观看视频| 床上黄色一级片| 99久国产av精品| 天堂中文最新版在线下载 | 婷婷色综合大香蕉| 精品人妻熟女av久视频| 不卡视频在线观看欧美| 舔av片在线| 别揉我奶头 嗯啊视频| 久久欧美精品欧美久久欧美| 大香蕉97超碰在线| 九草在线视频观看| 噜噜噜噜噜久久久久久91| 日韩欧美国产在线观看| 欧美bdsm另类| 在线免费观看不下载黄p国产| 一级黄色大片毛片| 最近中文字幕高清免费大全6| 国产日韩欧美在线精品| 色综合亚洲欧美另类图片| 久久99热6这里只有精品| 精品熟女少妇av免费看| av国产久精品久网站免费入址| 久久久精品大字幕| 哪个播放器可以免费观看大片| 国产淫片久久久久久久久| av免费观看日本| 国产精品嫩草影院av在线观看| 熟妇人妻久久中文字幕3abv| 色哟哟·www| 欧美高清性xxxxhd video| 天天躁夜夜躁狠狠久久av| 成人无遮挡网站| 中文资源天堂在线| 国产黄a三级三级三级人| 超碰97精品在线观看| 亚洲第一区二区三区不卡| 岛国在线免费视频观看| 伦精品一区二区三区| 一边亲一边摸免费视频| 一级爰片在线观看| 精品一区二区免费观看| 如何舔出高潮| 人人妻人人澡欧美一区二区| 亚洲国产精品成人久久小说| 欧美日韩一区二区视频在线观看视频在线 | 国产毛片a区久久久久| 色哟哟·www| 乱码一卡2卡4卡精品| 日本色播在线视频| 51国产日韩欧美| 最近中文字幕2019免费版| 国产精品女同一区二区软件| 亚洲av成人精品一区久久| 久久精品夜夜夜夜夜久久蜜豆| 三级国产精品片| 免费观看在线日韩| 国语对白做爰xxxⅹ性视频网站| 国产伦一二天堂av在线观看| 乱人视频在线观看| 国产日韩欧美在线精品| 久久婷婷人人爽人人干人人爱| 青春草国产在线视频| av在线蜜桃| 男女视频在线观看网站免费| 国产探花极品一区二区| 久久久久久大精品| 亚洲av成人精品一区久久| 最新中文字幕久久久久| 中文字幕制服av| 婷婷色麻豆天堂久久 | av播播在线观看一区| 成人性生交大片免费视频hd| 九九在线视频观看精品| 亚洲精品影视一区二区三区av| 亚洲国产日韩欧美精品在线观看| 久久精品综合一区二区三区| 大又大粗又爽又黄少妇毛片口| 精品国产三级普通话版| 国产精品蜜桃在线观看| 亚洲成人精品中文字幕电影| 51国产日韩欧美| 国产成人精品久久久久久| 美女内射精品一级片tv| 亚洲av二区三区四区| 免费观看人在逋| 人人妻人人看人人澡| 国产成年人精品一区二区| 蜜桃久久精品国产亚洲av| 只有这里有精品99| 99热全是精品| 国产三级中文精品| 国产中年淑女户外野战色| 国内精品美女久久久久久| 六月丁香七月| av福利片在线观看| 欧美成人一区二区免费高清观看| 在线a可以看的网站| 久久99热这里只频精品6学生 | 亚洲一级一片aⅴ在线观看| 亚洲av不卡在线观看| 国产午夜精品久久久久久一区二区三区| 99在线视频只有这里精品首页| 成人亚洲欧美一区二区av| 欧美zozozo另类| 亚洲国产日韩欧美精品在线观看| 激情 狠狠 欧美| 精品国内亚洲2022精品成人| 亚洲熟妇中文字幕五十中出| 久久久久久久亚洲中文字幕| 日韩欧美三级三区| 丝袜喷水一区| 在线免费观看的www视频| 内地一区二区视频在线| 亚洲成人精品中文字幕电影| 男人狂女人下面高潮的视频| 亚洲精品日韩av片在线观看| 久久精品国产99精品国产亚洲性色| 汤姆久久久久久久影院中文字幕 | 亚洲久久久久久中文字幕| av播播在线观看一区| 久久久国产成人免费| 国产伦一二天堂av在线观看| a级毛片免费高清观看在线播放| 黄色欧美视频在线观看| 2021天堂中文幕一二区在线观| 精品久久久久久久末码| 小说图片视频综合网站| 亚洲国产精品成人综合色| 搞女人的毛片| 超碰av人人做人人爽久久| 日日摸夜夜添夜夜添av毛片| 少妇裸体淫交视频免费看高清| 久久久欧美国产精品| 国产精品一区二区三区四区久久| 国产大屁股一区二区在线视频| 免费播放大片免费观看视频在线观看 | av在线亚洲专区| 嫩草影院精品99| 国产探花在线观看一区二区| 日本猛色少妇xxxxx猛交久久| 免费观看精品视频网站| 久久精品综合一区二区三区| 少妇的逼水好多| 精品久久久久久久久av| 亚洲人成网站在线观看播放| 国产视频首页在线观看| 久久久久久久久中文| a级毛片免费高清观看在线播放| 啦啦啦韩国在线观看视频| 国产成年人精品一区二区| 男女那种视频在线观看| 亚洲18禁久久av| 欧美97在线视频| 国产精品,欧美在线| 尤物成人国产欧美一区二区三区| 亚洲精品乱久久久久久| 成人美女网站在线观看视频| 国产亚洲午夜精品一区二区久久 | 色尼玛亚洲综合影院| 26uuu在线亚洲综合色| 久久久久久久国产电影| 搡女人真爽免费视频火全软件| 久久久久久久国产电影| 亚洲综合色惰| 国产色婷婷99| 九九热线精品视视频播放| 午夜免费男女啪啪视频观看| 青青草视频在线视频观看| 内射极品少妇av片p| 嫩草影院新地址| 国内精品一区二区在线观看| 国产精品久久视频播放| 国产精品久久久久久久电影| 一本一本综合久久| 亚洲精品亚洲一区二区| 青春草国产在线视频| 国产午夜精品久久久久久一区二区三区| 欧美丝袜亚洲另类| 91aial.com中文字幕在线观看| 在线免费观看不下载黄p国产| 日韩精品青青久久久久久| 日韩一区二区三区影片| 免费观看a级毛片全部| 欧美极品一区二区三区四区| 国产伦精品一区二区三区视频9| 免费黄网站久久成人精品| 午夜a级毛片| 尤物成人国产欧美一区二区三区| 亚洲国产欧洲综合997久久,| 看黄色毛片网站| 亚洲最大成人av| 欧美人与善性xxx| 国产高清有码在线观看视频| 国语自产精品视频在线第100页| av国产久精品久网站免费入址| 插逼视频在线观看| 简卡轻食公司| 中文欧美无线码| 中文字幕制服av| 久久久成人免费电影| 国产在线一区二区三区精 | 亚洲国产精品久久男人天堂| 黑人高潮一二区| 国产欧美日韩精品一区二区| 亚洲最大成人av| 久久热精品热| 麻豆av噜噜一区二区三区| 日本午夜av视频| 别揉我奶头 嗯啊视频| 美女黄网站色视频| 国产在线男女| 国产高清有码在线观看视频| 精品国产露脸久久av麻豆 | 麻豆av噜噜一区二区三区| 日本午夜av视频| 99久久人妻综合| 国产精品,欧美在线| 亚洲三级黄色毛片| 亚洲av电影在线观看一区二区三区 | 超碰97精品在线观看| 色噜噜av男人的天堂激情| 精品久久久久久久久久久久久| 国产高清视频在线观看网站| 小蜜桃在线观看免费完整版高清| 国产黄片视频在线免费观看| 欧美最新免费一区二区三区| 亚洲国产精品成人久久小说| 亚洲自拍偷在线| 国产精品久久电影中文字幕| 国产一区亚洲一区在线观看| 亚洲欧美成人精品一区二区| av在线播放精品| 欧美区成人在线视频| 一边摸一边抽搐一进一小说| ponron亚洲| 亚洲欧美精品专区久久| 超碰97精品在线观看| 国内揄拍国产精品人妻在线| 十八禁国产超污无遮挡网站| 97在线视频观看| 亚洲在久久综合| 久久韩国三级中文字幕| 亚洲电影在线观看av| 日韩 亚洲 欧美在线| 国产一区二区三区av在线| 成年av动漫网址| 国产欧美另类精品又又久久亚洲欧美| 日韩欧美在线乱码| 免费搜索国产男女视频| 国产极品精品免费视频能看的| 热99re8久久精品国产| 国产午夜精品久久久久久一区二区三区| 蜜桃久久精品国产亚洲av| 国产一区亚洲一区在线观看| 日日摸夜夜添夜夜添av毛片| 精品久久久久久久末码| 国内少妇人妻偷人精品xxx网站| 免费看av在线观看网站| 国产私拍福利视频在线观看| 久久这里有精品视频免费| 一个人免费在线观看电影| 一个人看的www免费观看视频| 国内精品宾馆在线| 亚洲欧美精品专区久久| 中文字幕人妻熟人妻熟丝袜美| 久久人人爽人人爽人人片va| 中国美白少妇内射xxxbb| 毛片一级片免费看久久久久| 中文天堂在线官网| 晚上一个人看的免费电影| 久久久久久久久大av| 联通29元200g的流量卡| 69人妻影院| 久久精品91蜜桃| 51国产日韩欧美| 少妇丰满av| 又黄又爽又刺激的免费视频.| 综合色av麻豆| 免费av不卡在线播放| 1024手机看黄色片| 国产午夜精品久久久久久一区二区三区| 色尼玛亚洲综合影院| 色哟哟·www| 国内精品一区二区在线观看| 亚洲欧美日韩高清专用| 中文欧美无线码| 中文字幕人妻熟人妻熟丝袜美| 色综合站精品国产| h日本视频在线播放| 老司机影院成人| 人人妻人人澡欧美一区二区| 午夜久久久久精精品| 亚州av有码| 国产日韩欧美在线精品| 色哟哟·www| 九草在线视频观看| 国产亚洲精品久久久com| 国产极品精品免费视频能看的| 男人和女人高潮做爰伦理| 免费看a级黄色片| 又爽又黄a免费视频| 淫秽高清视频在线观看| 老司机影院毛片| 午夜激情福利司机影院| 精品一区二区免费观看| 欧美高清成人免费视频www| 18禁在线无遮挡免费观看视频| 国产乱人视频| 亚洲图色成人| 97在线视频观看| 久久久久久久久久久免费av| 国产真实乱freesex| 黄片wwwwww| 久久精品熟女亚洲av麻豆精品 | 毛片女人毛片| 亚洲欧美精品专区久久| 亚洲人成网站高清观看| 久久99热这里只频精品6学生 | 午夜老司机福利剧场| 日产精品乱码卡一卡2卡三| av线在线观看网站| or卡值多少钱| 99视频精品全部免费 在线| 国产视频内射| 黑人高潮一二区| 日韩国内少妇激情av| 国产精华一区二区三区| 亚洲国产精品sss在线观看| 观看免费一级毛片| 午夜亚洲福利在线播放| 日本-黄色视频高清免费观看| 久久精品国产99精品国产亚洲性色| 国产欧美另类精品又又久久亚洲欧美| 精品少妇黑人巨大在线播放 | 成人三级黄色视频| 免费观看精品视频网站| 色播亚洲综合网| 成年女人看的毛片在线观看| 国产精品伦人一区二区| av又黄又爽大尺度在线免费看 | 中国国产av一级| 夜夜看夜夜爽夜夜摸| 男人狂女人下面高潮的视频| 国产国拍精品亚洲av在线观看| 大香蕉久久网| 午夜爱爱视频在线播放| 久久99热这里只有精品18| 国产午夜精品一二区理论片| 亚洲高清免费不卡视频| 只有这里有精品99| 精品久久久噜噜| 日本爱情动作片www.在线观看| 国产女主播在线喷水免费视频网站 | av黄色大香蕉| 乱人视频在线观看| 永久网站在线| 亚洲人成网站在线播| 成年女人永久免费观看视频| 国产老妇女一区| 99热这里只有是精品在线观看| 久久久久久久久久黄片| 黄色配什么色好看| 精品人妻熟女av久视频| 久久久久久伊人网av| 国产免费男女视频| 人妻少妇偷人精品九色| 亚洲av成人精品一二三区| 国产亚洲精品av在线| 国语对白做爰xxxⅹ性视频网站| 少妇人妻一区二区三区视频| 男女那种视频在线观看| 欧美zozozo另类| 波多野结衣高清无吗| 亚洲天堂国产精品一区在线| 国产精品女同一区二区软件| 永久免费av网站大全| 国产在线一区二区三区精 | 欧美变态另类bdsm刘玥| av国产久精品久网站免费入址| 91aial.com中文字幕在线观看| 国产淫语在线视频| 性插视频无遮挡在线免费观看| 免费看a级黄色片| 大又大粗又爽又黄少妇毛片口| 美女内射精品一级片tv| 中文欧美无线码| 美女被艹到高潮喷水动态| 六月丁香七月| 亚洲自拍偷在线| 免费一级毛片在线播放高清视频| 亚洲婷婷狠狠爱综合网| 日韩欧美精品v在线| 99久久精品一区二区三区| 国产在视频线精品| 少妇丰满av| 尾随美女入室| 精品欧美国产一区二区三| 亚洲精品成人久久久久久| 天堂av国产一区二区熟女人妻| 97热精品久久久久久|