楊新芳
[摘要] 目的 評(píng)價(jià)硫辛酸聯(lián)合前列地爾治療糖尿病足的療效。方法 對(duì)2017年7月—2019年10月至該院就診的糖尿病足患者,從中選擇102例作為該次研究的對(duì)象,系統(tǒng)隨機(jī)對(duì)患者進(jìn)行編號(hào),奇數(shù)為研究組,偶數(shù)為對(duì)照組,各組51例。兩組患者都接受了硫辛酸治療,研究組在此基礎(chǔ)上采用前列地爾治療。觀察兩組患者治療前后足背被動(dòng)脈血流動(dòng)力學(xué)指標(biāo)、血糖指標(biāo)、血清VEGF、bFGF及IGF-1 水平以及治療總有效率。結(jié)果 治療后,研究組足背動(dòng)脈血流動(dòng)力學(xué)指標(biāo)、血清VEGF、bFGF、IGF-1水平、血糖指標(biāo)均優(yōu)于對(duì)照組(P<0.05),研究組治療總有效率、不良反應(yīng)發(fā)生率優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 對(duì)糖尿病足患者采用硫辛酸聯(lián)合前列地爾治療能夠顯著改善患者足背動(dòng)脈血流動(dòng)力學(xué),可明顯提高糖尿病足患者血清VEGF、bFGF 和 IGF-1水平,可有效控制患者血糖,不良反應(yīng)發(fā)生率更低,療效更為確切。
[關(guān)鍵詞] 糖尿病足;血清VEGF;IGF-1;bFGF;總有效率
[中圖分類號(hào)] R587.1 ? ? ? ? ?[文獻(xiàn)標(biāo)識(shí)碼] A ? ? ? ? ?[文章編號(hào)] 1672-4062(2020)11(a)-0183-03
[Abstract] Objective To evaluate the efficacy of lipoic acid combined with alprostadil in the treatment of diabetic foot. Methods From July 2017 to October 2019, 102 patients with diabetic foot were selected as the subjects of this study. The patients were randomly numbered. The odd number was the study group, the even number was the control group, and 51 patients in each group. Both groups were treated with lipoic acid, and the study group was treated with alprostadil. The hemodynamic indexes, blood glucose indexes, serum VEGF, bFGF and IGF-1 levels of dorsalis pedis artery before and after treatment were observed. Results After treatment, the indexes of hemodynamics, VEGF, bFGF, IGF-1 and blood glucose in the study group were better than those in the control group(P<0.05). The total effective rate and the incidence of adverse reactions in the study group were better than those in the control group, the difference was statistically significant(P<0.05). Conclusion The treatment of lipoic acid combined with alprostadil can significantly improve the hemodynamics of dorsalis pedis, increase the levels of VEGF, bFGF and IGF-1 in the serum of diabetic foot patients, effectively control the blood glucose of diabetic foot patients, reduce the incidence of adverse reactions, and achieve more accurate results.
[Key words] Diabetic foot; Serum VEGF; IGF-1; bFGF; Total effective rate
2型糖尿病是臨床最為常見(jiàn)的糖尿病類型,而糖尿病足是2型糖尿病患者常見(jiàn)的并發(fā)癥之一。糖尿病足患者若不及時(shí)接受治療,病情進(jìn)展快,嚴(yán)重的可危及患者生命??刂蒲恰⒏腥緞?chuàng)面清創(chuàng)是治療糖尿病足的常規(guī)治療手段,但這一治療方法治療時(shí)間長(zhǎng),且患者面臨較高的截肢風(fēng)險(xiǎn)。硫辛酸是臨床治療糖尿病的一線用藥,在改善神經(jīng)感覺(jué)癥狀、保護(hù)血管內(nèi)皮功能方面有著良好的效果。前列地爾是一種血管活性藥物,目前已被廣泛地應(yīng)用于糖尿病的臨床治療中。為了探討二者聯(lián)合用藥治療糖尿病足的療效,該研究對(duì)該院2017年7月—2019年10月收治的102例糖尿病足患者,系統(tǒng)隨機(jī)對(duì)患者進(jìn)行編號(hào),奇數(shù)為研究組,偶數(shù)為對(duì)照組,各組51例,進(jìn)行了對(duì)比研究,現(xiàn)報(bào)道如下。
1 ?資料與方法
1.1 ?一般資料
對(duì)該院就診的糖尿病足患者,從中選擇102例作為該次研究的對(duì)象,系統(tǒng)隨機(jī)對(duì)患者進(jìn)行編號(hào),奇數(shù)為研究組,偶數(shù)為對(duì)照組,各組51例。研究組男性與女性患者比為29:22;患者最大年齡為78歲,最小年齡為42歲,平均(60.58±1.63)歲;糖尿病病程為5~13年,平均(8.30±0.42)年;Wanger Ⅰ級(jí)16例,Ⅱ級(jí)23例,Ⅲ級(jí)12例。對(duì)照組中男性與女性患者比為28:23;患者最大年齡為81歲,最小年齡為44歲,平均(61.13±1.58)歲;糖尿病病程為5~13年,平均(8.10±0.39)年;Wanger Ⅰ級(jí)13例,Ⅱ級(jí)24例,Ⅲ級(jí)14例。兩組患者一般資料差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05),可以比較。