• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Effects of Chaihu Guizhi Ganjiang Decoction Combined with Standard Triple Therapy on Reducing Serum CagA and Hp-NAP in Patients with H.pylori-Related Gastritis

    2018-10-30 08:34:52YangWeixia楊為霞WangJinhua王金華ChenZhaoyang陳兆洋ZhangFeng
    關(guān)鍵詞:金華

    Yang Weixia (楊為霞), Wang Jinhua (王金華), Chen Zhaoyang (陳兆洋), Zhang Feng (張 鳳)

    Department of Internal Medicine of Traditional Chinese Medicine, Dachang Hospital, Shanghai 200436, China

    ABSTRACT OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction.The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay (ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention (P > 0.05).After intervention, CagA and Hp-NAP concentrations in experimental group were (19.21±6.27) ng/L and (24.37±6.10)ng/L respectively which were lower than (25.81±7.14) ng/L and (32.09±5.73) ng/L of control group. The differences were statistically significant (P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group (31 cases, 75.61%). There was statistically significant difference between the 2 groups (P < 0.05). The eradication rate of H.pylori was 38 cases (92.68%) in the experimental group, which was significantly higher than 31 cases (75.61%) of the control group. The difference between the 2 groups was statistically significant (P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis,improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.

    KEYWORDS: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy; H.pylori-relatated gastritis; Symptomatic efficacy; H.pylori eradication rate

    Chronic gastritis is a common disease with high incidence. Helicobacter is one of the major causes[1].The clinical symptoms of H.pylori-related gastritis are epigastric dull pain, fullness in the epigastrium, sour regurgitation, heartburn, dry mouth, bitter taste, loose stools, nausea, vomiting. It will lead to weight loss, which seriously affects patients' physical health and quality of life[2,3]. Long periods of the H.pylori infection will lead to intestinal epithelium metaplasia or gastric mucosa atrophy,which will possibly develop into carcinomatous change[4].At the present stage, H.pylori infection has become a global issue. The rate of H.pylori infection is 40%-90% in China. The key of the H.pylori related gastritis preservation and treatment is to release inflammation[5,6]reaction and to eliminate alimentary symptoms. Recently, Western Medicine has made some progress in the treatment of the H.pylori related gastritis. However, unstrict usage of the antibiotics makes H.pylori tolerance rise, which is more difficult to achieve ideal eradication rate[7,8]. This study made some achievements in treating H.pylori related gastritis by standard triple therapy combined with Chaihu Guizhi Ganjiang Decoction.

    DATA AND METHODS

    General data

    A total of 82 cases of H.pylori related gastritis patients treated in our hospital from January 2016 to December 2017 were selected. Among those cases, there are 51 male patients and 31 female patients, whose age ranged from 16 to 67 years old. Its average age was 47.28±7.82 years old and the course of disease ranged from 1 to 13 years. Its average course was 6.72±1.32 years. According to random table method, all patients were divided into experimental group and control group,with 41 patients in each one. There were 26 male patients,15 female patients in the experimental group, and their average age was 47.31±7.64 years old. The average course of the treatment was 6.82±1.28 years. There were 25 male patients, 16 female patients in the control group.Their average age ranged was 46.97±7.92 years old. The average course was 6.62±1.30 years. The 2 groups had no statistical differences in sex, age and course (P > 0.05).

    Inclusion criteria: ① All patients are diagnosed as H.pylori related gastritis patients by electric gastroscope,14C breath test and gastric musoca pathologic detection.② The patients had not administrated gastric mucosa protectant, proton pump inhibitor, antibiotics, antacids and so on, which could affect prescriptions used in study in 2 weeks before study. ③ Patients and their families know and agree with this study.

    Exclusion criteria: ① The patients are pregnant or in lactation period. ② The patients have serious hemorrhage of digestive tract, pyloric obstruction and serious stomach operation history. ③ The patients may have tumor of other systems. ④ The patients also have renal insufficiency, diabetes mellitus, hematopoiesis system diseases or serious cardiovascular diseases. This study was approved by the hospital ethics committee.

    Methods

    The observation group adopted standard triple therapy. The specific methods were as follows: ① The patients took Omeprazole twice a day and 20 mg for one dosage. ② The patients took Aspirin twice a day and 1 g for one dosage. ③ The patients took Metronidazole twice a day and 0.4 g for one dosage. If patients are allergic to Aspirin, they took Claricid twice a day and 0.5 g for one dosage. 14 days is one course.

    Additionally, the experimental group was administrated with Modified Chaihu Guizhi Ganjiang Decoction. The specific methods were as follows: ① Chaihu Guizhi Ganjiang Decoction was composed of Radix Stellariae 15 g, Ramulus Cinnamomi 6 g, Rhizoma Zingiberis 6 g,Radix et Rhizoma Glycyrrhizae Praeparata cum Melle 8 g,Radix Scutellariae Hypericifoliae 15 g, Fructus Trichosanthis 20 g, Concha Ostreae 15 g. If patients had serious gastralgia,add Rhizoma Corydalis. If patients had acid regurgitation,add cuttle bone. If patients had abdominal distension,add Fructus Aurantii, Pericarpium Citri Reticulatae. If patients had constipation, add Semen Cassiae. ② The herbs mentioned above should be sank in 600 mL water for 30 minutes and decocted with strong fire, and then change to mild fire for 30 minutes. The 200 mL decoction was obtained. After that, add 300 mL water, and decocted with strong fire, then changed to mild fire. Finally 150 mL decoction was obtained. ③ Mix 150 mL decoction with 300 mL decoction and take it twice a day in the morning and evening for each. 14 days as one treatment course.

    Diagnosis criteria

    H.pylori infection diagnosis criteria

    ① H.pylori thallus was found in tissue section of gastric mucosa in patients. ②14C breath test of patients is positive. Patients accords with any one of above can be diagnosed as H.pylori infection.

    Diagnosis criteria of chronic gastritis

    Diagnosis criteria of chronic gastritis according to Study of clinical digestion diseases of traditional and western medicine: ① The results of fiber gastroscope show patients have gastric mucosa edema, hyperemia, gastric mucosa dot,hemorrhage or erosion. ② More than 2 symptoms of those symptoms in patients appeared, including acid regurgitation,stomach pain, gastric upset, abdominal distension, belching,sour regurgitation, heartburn and so on.

    Observation index

    CagA, Hp-NAP concentration of serum in patients

    Venous blood of elbow was taken and enzymelinked immunosorbent assay was used to detect CagA and Hp-NAP concentration of serum in patients of the 2 groups before and after treatment

    Efficacy on primary symptoms

    The symptom grade was assessed based on conditions of acid regurgitation, stomach pain, gastric upset, abdominal distension, belching, and tongue and pulse manifestation before and after intervention.The grades were calculated according to symptommanifestation, and the specific methods were as follows:① Adopt classification rating scale to calculate grades and to classify 4 levels based on their conditions. ② The grade is 0, if patients have no symptoms. ③ The grade is 1, if patients have slight abnormal feelings. ④ The grade is 2, if symptoms are marked and do not affect normal life. ⑤ The grade is 3, if symptoms manifest as inflammation and seriously affect normal life of patients.

    Table 1. Comparison of CagA, Hp-NAP concentration of serum in the 2 groups' patients (ng/L)

    Table 2. Comparison of efficacy on primary symptoms between the 2 groups

    The symptoms therapeutic effects were evaluated according to the changes of symptoms scores before and after intervention conditions: ① Basically patients whose symptoms disappear and symptoms grade has decreased up to 95% are viewed as cured cases. ② Patients whose symptoms have been improved markedly and whose symptoms grade has decreased up to 75% to 95% are viewed as markedly effective cases. ③ Patients whose symptoms have been slightly improved and whose symptoms grade has decreased up to 35% to 75% are viewed as effective cases. ④ Patients whose symptoms have not been improved and whose symptoms grade has decreased below 35% are viewed as an ineffective cases.

    The total effective cases = cured cases + markedly effective cases + effective cases

    The H.pylori eradicating rate of the 2 groups was calculated. The eradicating criteria of H.pylori:14C breath test was conducted after 4 weeks of drug suspension.H.pylori is eradicated if the detect result is negative.

    Statistical methods

    SPSS 19.0 was adopted to analyze data in this study.Measurement data was tested by t test. Enumeration data was tested by χ2test. The difference between the 2 groups'data has statistical significance when P < 0.05.

    RESULTS

    CagA, Hp-NAP concentration of serum in the 2 groups

    The CagA, Hp-NAP concentration difference between the 2 groups had no statistical significance before intervention(P > 0.05). The CagA, Hp-NAP concentration in experimental group was lower than that of control group, and the difference was statistically significant (P < 0.05). See Table 1.

    Comparison of efficacy on primary symptoms between the 2 groups

    The total effective rate of primary symptoms of experimental group was markedly higher than that of control group. The difference between the 2 groups had statistical significance (P < 0.05). See Table 2.

    H.pylori eradicating rate of the 2 groups

    H.pylori eradicating rate of experimental group was markedly higher that that of control group. The difference between the 2 groups had statistical significance (P < 0.05).See Table 3.

    Table 3. Comparison of H.pylori eradicating rate between the 2 groups (cases (%))

    DISCUSSION

    H.pylori related gastritis is a common clinical digestive disease, which mainly manifests as epigastric distension, epigastric pain, epigastric upset and so on[9]. Doctors of Western Medicine perceive that main toxicological factor is CagA, which affects development of chronic gastritis through impairing gastric mucosa cells. Besides, Hp-NAP, one of extracts of H.pylori,exerts an active influence on inflammation cells and when combined with specificity receptor, it will activate damage, proliferation and apoptosis of DNA in cells[10-11].If Helicobacter pylori acts on gastric mucosa without immediate treatment for a long time, it will act as promotor, which will gradually make chronic gastritis develop to gland atrophy, intestine epithelial metaplasia,or even, carcinogenesis[12]. Recently western medicine conventionally adopts triple therapy to treat H.pylori related gastritis. However, drug-resistance of H.pylori has risen gradually and eradicating rate fails to achieve patients' expectation since abuse of various antibiotics[13].Chinese medicine holds that this disease derives from dampness-heat of spleen and stomach, of which deficiency of spleen and stomach is the root cause and dampnessheat blocking middle-energizer is the manifestation[14].Chaihu Guizhi Ganjiang Decoction is from Treatise on Cold Damage, of which Fructus Trichosanthis can clear heat and promote fluid production, Radix Stellariae and Radix Scutellariae Hypericifoliae can reconcile shaoyang and disperse the stagnated liver qi, Ramulus Cinnamoni and Rhizoma Zingiberis can warm yang and expell coldness. This formula can disperse the stagnated liver qi for relieving qi stagnation and warmly invigorate spleen yang.

    CagA and Hp-NAP concentration in patients of the 2 groups before intervention in this study has no statistical significance (P > 0.05), while after intervention CagA and Hp-NAP concentration in patients of experimental group was lower than that of observation group (P < 0.05), indicating that there is statistical significance. It shows Chaihu Guizhi Ganjiang Decoction combined with triple therapy can effectively reduce CagA and Hp-NAP concentration in serum of patients. The reason is Chaihu Guizhi Ganjiang Decoction can effectively disperse the stagnated liver qi for relieving qi stagnation and warmly invigorate spleen yang. Some study shows digestive diseases caused by H.pylori mostly are dampness-heat of spleen and stomach syndrome[15]. Positive rate in patients of this pattern is markedly higher that of other patterns. H.pylori eradicating rate could rise after treating from warmly invigorating spleen yang. After that extract, Hp-NAP, and toxicological factor CagA concentration will decrease. In this study, the total effective rate of primary symptoms in patients from experimental group was higher than that of control group. Data from the 2 groups had statistical significance (P < 0.05). The possible reason might be, to some extent, antibiotics abuse exerts negative influence on conventional treatment of triple therapy. In this study,although triple therapy improves H.pylori related gastritis to some extent, its therapeutic effects decrease with enhance of H.pylori resistance. Chaihu Guizhi Ganjiang Decoction combined with triply therapy can make up for bad therapeutic effects attributing to resistance increase. Thus, total effective rate of main symptoms in experimental group is clearly higher than that of control group. In this study, the eradicating rate of H.pylori in experimental group was obviously higher than that of control group. The difference between the 2 groups had statistical significance (P < 0.05). The possible reason might be abuse of antibiotics leading to the increase of H.pylori resistance and triple therapy is still used to treat diseases. As a result of that, eradicating rate was low.Adopting Chaihu Guizhi Ganjinag Decoction on the basis of triple therapy can effectively remedy this problem.

    All in all, Chaihu Guizhi Ganjiang Decoction combined with conventional triple therapy can effectively decrease Cag and Hp-NAP concentration of serum in patients of H.pylori related gastritis, improve therapeutic effects and eradicating rate of H.pylori, which deserves clinical promoting.

    猜你喜歡
    金華
    張金華
    大江南北(2022年11期)2022-11-08 12:04:18
    歲朝清供
    寶藏(2021年1期)2021-03-10 11:06:18
    壽鶴延年
    寶藏(2021年1期)2021-03-10 11:06:16
    陶金華
    安金華 藏石欣賞
    寶藏(2018年12期)2019-01-29 01:50:56
    那個(gè)春天(散文)
    陳金華
    銀胡子爺爺?shù)漠?huà)
    紅氣球請(qǐng)客
    紅氣球請(qǐng)客
    亚洲18禁久久av| 成人永久免费在线观看视频| 少妇熟女欧美另类| 一个人免费在线观看电影| 国产精品爽爽va在线观看网站| 国产成人91sexporn| avwww免费| 男女下面进入的视频免费午夜| 最好的美女福利视频网| 自拍偷自拍亚洲精品老妇| 91午夜精品亚洲一区二区三区| 国产精品综合久久久久久久免费| 国产精品人妻久久久久久| 国内精品久久久久精免费| 亚洲色图av天堂| 又粗又爽又猛毛片免费看| 亚洲熟妇中文字幕五十中出| 亚洲欧美清纯卡通| 久久久久久久亚洲中文字幕| 内射极品少妇av片p| 国产精品一区二区在线观看99 | 亚洲精品456在线播放app| 一进一出抽搐动态| 久久久久久久久久久丰满| 国产精品99久久久久久久久| 婷婷色综合大香蕉| 91久久精品国产一区二区成人| 国产精品伦人一区二区| 一本精品99久久精品77| 国产91av在线免费观看| 美女黄网站色视频| 久久精品国产亚洲av香蕉五月| 亚洲欧洲国产日韩| 国产伦精品一区二区三区视频9| 色噜噜av男人的天堂激情| 欧美日韩精品成人综合77777| 精品久久久久久久久亚洲| 美女大奶头视频| 日日撸夜夜添| 黑人高潮一二区| 高清日韩中文字幕在线| 天堂√8在线中文| 欧美日韩乱码在线| 禁无遮挡网站| 亚洲在线观看片| 欧美三级亚洲精品| 国产亚洲91精品色在线| 精品无人区乱码1区二区| 国产色爽女视频免费观看| 韩国av在线不卡| 免费观看a级毛片全部| 91午夜精品亚洲一区二区三区| 日本免费一区二区三区高清不卡| 三级国产精品欧美在线观看| 亚洲一区二区三区色噜噜| 悠悠久久av| 亚洲成人久久性| 免费看a级黄色片| 日韩中字成人| 日日撸夜夜添| 久久久久久国产a免费观看| 偷拍熟女少妇极品色| 亚洲欧美清纯卡通| 性欧美人与动物交配| 又爽又黄a免费视频| 三级男女做爰猛烈吃奶摸视频| 男女做爰动态图高潮gif福利片| 国产成人a∨麻豆精品| 久久精品国产亚洲av天美| 大香蕉久久网| 日韩欧美三级三区| 精品一区二区三区视频在线| 免费观看精品视频网站| 久久欧美精品欧美久久欧美| 综合色丁香网| 一卡2卡三卡四卡精品乱码亚洲| 人妻制服诱惑在线中文字幕| 亚洲欧洲国产日韩| 亚洲va在线va天堂va国产| 精品一区二区三区视频在线| 波多野结衣巨乳人妻| 岛国毛片在线播放| 91aial.com中文字幕在线观看| 深爱激情五月婷婷| 欧美另类亚洲清纯唯美| 夜夜看夜夜爽夜夜摸| 亚州av有码| 国产亚洲精品久久久com| 亚洲第一电影网av| 国产精品久久久久久久电影| 国产成人福利小说| 日本撒尿小便嘘嘘汇集6| 国产免费男女视频| 久久久久久伊人网av| 卡戴珊不雅视频在线播放| 国产久久久一区二区三区| 成人高潮视频无遮挡免费网站| 色5月婷婷丁香| 日韩视频在线欧美| 欧美激情在线99| 色综合站精品国产| 亚洲av第一区精品v没综合| 美女cb高潮喷水在线观看| 狂野欧美白嫩少妇大欣赏| 亚洲精品乱码久久久v下载方式| 成人午夜精彩视频在线观看| 国产精品一区二区在线观看99 | 亚洲国产欧美在线一区| 国产男人的电影天堂91| 淫秽高清视频在线观看| 亚洲av熟女| 国产精品嫩草影院av在线观看| 美女高潮的动态| 亚洲在线自拍视频| 国产成人午夜福利电影在线观看| 网址你懂的国产日韩在线| 免费观看在线日韩| 2021天堂中文幕一二区在线观| 国产精品一及| 99riav亚洲国产免费| 国产大屁股一区二区在线视频| 亚洲欧美精品自产自拍| 黄色视频,在线免费观看| 久久草成人影院| 看十八女毛片水多多多| 亚洲国产欧洲综合997久久,| 青春草国产在线视频 | 有码 亚洲区| 久久精品国产亚洲网站| 国产毛片a区久久久久| 亚洲综合色惰| 国产中年淑女户外野战色| 久久亚洲国产成人精品v| 美女大奶头视频| 亚洲婷婷狠狠爱综合网| 中文字幕久久专区| 人人妻人人澡欧美一区二区| 国产精品久久视频播放| av专区在线播放| 久久人人精品亚洲av| 丝袜美腿在线中文| 国产探花在线观看一区二区| 少妇丰满av| 午夜老司机福利剧场| 黄色欧美视频在线观看| 只有这里有精品99| 亚洲欧美清纯卡通| 久久久久久久久久成人| 日韩欧美一区二区三区在线观看| 在线免费观看不下载黄p国产| 欧美人与善性xxx| 亚洲欧洲国产日韩| 最近的中文字幕免费完整| 久久精品国产亚洲av涩爱 | 天堂av国产一区二区熟女人妻| av天堂在线播放| 嫩草影院新地址| 久久久久久久久久久丰满| 亚洲中文字幕一区二区三区有码在线看| 国产精品日韩av在线免费观看| 女人被狂操c到高潮| 亚洲色图av天堂| 国产男人的电影天堂91| 欧美极品一区二区三区四区| 亚洲成人久久性| 少妇裸体淫交视频免费看高清| 亚洲精品乱码久久久v下载方式| 亚洲欧美精品自产自拍| 深爱激情五月婷婷| 大又大粗又爽又黄少妇毛片口| 国产精品福利在线免费观看| 亚洲欧美清纯卡通| 国产探花在线观看一区二区| 亚洲成人av在线免费| 性欧美人与动物交配| 韩国av在线不卡| 精品99又大又爽又粗少妇毛片| 久久久欧美国产精品| av福利片在线观看| 国产亚洲5aaaaa淫片| 国产一区二区激情短视频| 亚洲av熟女| 99热这里只有是精品在线观看| 国产又黄又爽又无遮挡在线| 三级经典国产精品| 此物有八面人人有两片| 草草在线视频免费看| 一级毛片久久久久久久久女| 一级黄片播放器| 国产毛片a区久久久久| 亚洲av成人av| 亚洲不卡免费看| 两个人的视频大全免费| 欧美在线一区亚洲| 在线国产一区二区在线| 免费电影在线观看免费观看| 男人狂女人下面高潮的视频| 国产爱豆传媒在线观看| 国产成人影院久久av| 国产午夜精品一二区理论片| 搡女人真爽免费视频火全软件| 精品一区二区三区视频在线| 成人亚洲欧美一区二区av| 亚洲无线在线观看| 一本精品99久久精品77| 欧美日本亚洲视频在线播放| 国产老妇伦熟女老妇高清| 成人永久免费在线观看视频| 精品久久国产蜜桃| 成年av动漫网址| 欧美一区二区精品小视频在线| 狠狠狠狠99中文字幕| 亚洲在线观看片| 哪个播放器可以免费观看大片| 久久国内精品自在自线图片| 亚洲经典国产精华液单| 国国产精品蜜臀av免费| 国产91av在线免费观看| 最好的美女福利视频网| 久99久视频精品免费| 色综合色国产| 乱人视频在线观看| 精品久久久久久久久久免费视频| 少妇丰满av| 国产成人aa在线观看| 国产精品.久久久| 亚洲国产欧美人成| 精品久久久久久久久久免费视频| 国产伦精品一区二区三区视频9| 在线免费观看不下载黄p国产| 国产精品一区二区在线观看99 | 久久欧美精品欧美久久欧美| 老司机影院成人| 国产探花极品一区二区| 久久久精品欧美日韩精品| 国产在视频线在精品| 自拍偷自拍亚洲精品老妇| 午夜福利视频1000在线观看| 国产成人freesex在线| 99在线人妻在线中文字幕| 蜜桃久久精品国产亚洲av| 亚洲精品日韩在线中文字幕 | 大型黄色视频在线免费观看| 久久午夜亚洲精品久久| 成人亚洲欧美一区二区av| 99九九线精品视频在线观看视频| 啦啦啦韩国在线观看视频| 欧美日本亚洲视频在线播放| 国产美女午夜福利| 精品一区二区三区人妻视频| 国模一区二区三区四区视频| 久久久久免费精品人妻一区二区| 哪里可以看免费的av片| 国产 一区 欧美 日韩| 日韩欧美精品v在线| 国产真实乱freesex| 国产高清不卡午夜福利| 国产黄片视频在线免费观看| av在线亚洲专区| 国产成人精品婷婷| 国产大屁股一区二区在线视频| 深夜a级毛片| 国产美女午夜福利| 你懂的网址亚洲精品在线观看 | 欧美另类亚洲清纯唯美| 国产精品福利在线免费观看| 午夜激情福利司机影院| ponron亚洲| 天天躁日日操中文字幕| 99久久人妻综合| 亚洲国产精品久久男人天堂| 精品日产1卡2卡| 国产精品99久久久久久久久| 搡女人真爽免费视频火全软件| 1024手机看黄色片| 成人高潮视频无遮挡免费网站| 99久久中文字幕三级久久日本| 99riav亚洲国产免费| 国产69精品久久久久777片| 亚洲av中文字字幕乱码综合| 午夜福利在线观看免费完整高清在 | 亚洲精品日韩av片在线观看| 亚洲av一区综合| 亚洲国产精品国产精品| 国产成人精品久久久久久| 99热只有精品国产| 最近手机中文字幕大全| 亚洲成av人片在线播放无| 搡女人真爽免费视频火全软件| av在线天堂中文字幕| 国产精品蜜桃在线观看 | 美女国产视频在线观看| 天美传媒精品一区二区| 蜜桃亚洲精品一区二区三区| 啦啦啦观看免费观看视频高清| 亚洲性久久影院| 寂寞人妻少妇视频99o| 欧美性猛交黑人性爽| 亚洲一区高清亚洲精品| 熟妇人妻久久中文字幕3abv| 欧美又色又爽又黄视频| 美女xxoo啪啪120秒动态图| 韩国av在线不卡| 色尼玛亚洲综合影院| 全区人妻精品视频| 久久人人精品亚洲av| 69人妻影院| 在线播放国产精品三级| 亚洲第一区二区三区不卡| 丰满的人妻完整版| 欧美色视频一区免费| 中文字幕久久专区| 久久精品91蜜桃| 波多野结衣高清作品| 色视频www国产| 一个人看视频在线观看www免费| 成人毛片a级毛片在线播放| 成人三级黄色视频| 狂野欧美激情性xxxx在线观看| 国产人妻一区二区三区在| 国内精品久久久久精免费| 国产成人精品久久久久久| 婷婷色综合大香蕉| 亚洲内射少妇av| 欧美在线一区亚洲| 51国产日韩欧美| 国产日韩欧美在线精品| 成人毛片a级毛片在线播放| 国产精品女同一区二区软件| 欧美成人免费av一区二区三区| 久久久久久久久久成人| 久久精品国产清高在天天线| 免费搜索国产男女视频| 精品国内亚洲2022精品成人| 国内精品美女久久久久久| 免费av毛片视频| 国产淫片久久久久久久久| 天堂网av新在线| 欧美又色又爽又黄视频| 日日干狠狠操夜夜爽| 级片在线观看| www.av在线官网国产| 亚洲乱码一区二区免费版| 亚洲七黄色美女视频| 成人二区视频| 国产伦精品一区二区三区四那| 久久国产乱子免费精品| 黄色视频,在线免费观看| 国内久久婷婷六月综合欲色啪| 成人毛片a级毛片在线播放| 国产精品三级大全| 久久久色成人| 中文字幕久久专区| 99久久精品热视频| 精品无人区乱码1区二区| 亚洲最大成人中文| 亚洲一级一片aⅴ在线观看| 亚洲va在线va天堂va国产| 天堂网av新在线| 国产精品久久久久久亚洲av鲁大| 最近视频中文字幕2019在线8| 午夜激情欧美在线| 国产伦理片在线播放av一区 | 久久久色成人| 午夜免费男女啪啪视频观看| 波多野结衣高清无吗| 六月丁香七月| 中文字幕制服av| 99热全是精品| 观看免费一级毛片| .国产精品久久| a级毛片免费高清观看在线播放| 国产亚洲精品久久久com| 亚洲国产精品国产精品| 日本熟妇午夜| 日韩精品有码人妻一区| 非洲黑人性xxxx精品又粗又长| 在线天堂最新版资源| 欧美在线一区亚洲| 在线播放无遮挡| 久久久久久久久大av| 干丝袜人妻中文字幕| 看十八女毛片水多多多| 哪里可以看免费的av片| 又爽又黄无遮挡网站| 欧美三级亚洲精品| 亚洲av一区综合| 午夜精品一区二区三区免费看| 不卡一级毛片| а√天堂www在线а√下载| 亚洲欧美日韩高清在线视频| 免费观看a级毛片全部| 给我免费播放毛片高清在线观看| 日韩国内少妇激情av| 亚洲精品粉嫩美女一区| 午夜福利成人在线免费观看| 国内精品美女久久久久久| av在线天堂中文字幕| 国产亚洲av片在线观看秒播厂 | 欧美丝袜亚洲另类| 亚洲乱码一区二区免费版| 男人狂女人下面高潮的视频| 精品国产三级普通话版| 观看免费一级毛片| 精品久久国产蜜桃| 亚洲性久久影院| 国产高清有码在线观看视频| 三级经典国产精品| 国产成人影院久久av| 不卡一级毛片| 久久人人爽人人片av| 中文欧美无线码| 精品日产1卡2卡| 久久99热这里只有精品18| 真实男女啪啪啪动态图| 少妇的逼好多水| 国产av麻豆久久久久久久| 九九热线精品视视频播放| 人人妻人人看人人澡| 在线观看美女被高潮喷水网站| 免费看光身美女| 免费搜索国产男女视频| 国产极品精品免费视频能看的| 国产精品久久久久久精品电影小说 | 日本与韩国留学比较| 啦啦啦啦在线视频资源| 哪个播放器可以免费观看大片| 精品久久久久久成人av| 亚州av有码| 免费一级毛片在线播放高清视频| 美女xxoo啪啪120秒动态图| 少妇熟女aⅴ在线视频| 亚洲高清免费不卡视频| 色哟哟哟哟哟哟| 可以在线观看的亚洲视频| 男人舔奶头视频| 一级av片app| 国产不卡一卡二| 午夜久久久久精精品| 中文精品一卡2卡3卡4更新| 小蜜桃在线观看免费完整版高清| 免费观看人在逋| 三级经典国产精品| 日韩亚洲欧美综合| 免费看a级黄色片| 午夜精品国产一区二区电影 | 老司机福利观看| 久久久久久久久大av| 联通29元200g的流量卡| 18禁在线播放成人免费| 国产毛片a区久久久久| 国产成人影院久久av| 一区二区三区高清视频在线| 性欧美人与动物交配| 草草在线视频免费看| 国产日韩欧美在线精品| 国产精品精品国产色婷婷| 日本熟妇午夜| 99久久精品国产国产毛片| 亚洲激情五月婷婷啪啪| 如何舔出高潮| 日韩三级伦理在线观看| 国产亚洲精品av在线| 久久6这里有精品| 欧美日韩综合久久久久久| 在线免费十八禁| 日韩人妻高清精品专区| 一级av片app| 亚洲av男天堂| 色播亚洲综合网| 一级毛片我不卡| 老熟妇乱子伦视频在线观看| 最近中文字幕高清免费大全6| 欧美日韩国产亚洲二区| 欧美性猛交╳xxx乱大交人| 国产在线男女| 岛国毛片在线播放| 亚洲av第一区精品v没综合| 成年版毛片免费区| 精品一区二区三区视频在线| 国产 一区精品| 看非洲黑人一级黄片| 国产高清三级在线| 国产精品精品国产色婷婷| 国语自产精品视频在线第100页| 一本一本综合久久| 国产精品福利在线免费观看| 成人三级黄色视频| 精品人妻一区二区三区麻豆| 国产精品三级大全| 国内精品一区二区在线观看| 男插女下体视频免费在线播放| 亚洲精品日韩在线中文字幕 | 久久午夜亚洲精品久久| 只有这里有精品99| 级片在线观看| 中文字幕熟女人妻在线| h日本视频在线播放| 男人和女人高潮做爰伦理| 国产av在哪里看| 国产一区亚洲一区在线观看| 欧美高清成人免费视频www| 亚洲国产精品成人综合色| av在线蜜桃| 成人二区视频| 亚洲自偷自拍三级| 国产免费男女视频| 久久久国产成人精品二区| 美女国产视频在线观看| 午夜视频国产福利| 性插视频无遮挡在线免费观看| 国产精品一区二区性色av| 婷婷色av中文字幕| 日韩在线高清观看一区二区三区| 六月丁香七月| 亚洲精品乱码久久久久久按摩| 国产精品蜜桃在线观看 | 直男gayav资源| 成年女人永久免费观看视频| 最近的中文字幕免费完整| 亚洲精品成人久久久久久| 久久人妻av系列| 中国国产av一级| 女同久久另类99精品国产91| 人妻系列 视频| 亚洲av.av天堂| 成人午夜精彩视频在线观看| 观看美女的网站| 国产极品精品免费视频能看的| 夜夜夜夜夜久久久久| 免费av毛片视频| 97超碰精品成人国产| 精品久久久久久久末码| 久久热精品热| 色尼玛亚洲综合影院| 久久久久久大精品| 国产老妇女一区| 99热这里只有是精品在线观看| 国产私拍福利视频在线观看| 97超碰精品成人国产| 一级毛片我不卡| 欧美日本亚洲视频在线播放| 国产在线精品亚洲第一网站| 免费看美女性在线毛片视频| 永久网站在线| 老司机福利观看| 国产黄a三级三级三级人| 国产伦理片在线播放av一区 | 亚洲色图av天堂| 国产麻豆成人av免费视频| 久久亚洲精品不卡| 欧美高清成人免费视频www| 在线观看午夜福利视频| 亚洲乱码一区二区免费版| 久久久久久久亚洲中文字幕| 青青草视频在线视频观看| 国产成人精品久久久久久| 极品教师在线视频| 99在线人妻在线中文字幕| 伦理电影大哥的女人| 最近的中文字幕免费完整| 日韩欧美一区二区三区在线观看| 国产精品不卡视频一区二区| 亚洲aⅴ乱码一区二区在线播放| 欧美激情国产日韩精品一区| 亚洲婷婷狠狠爱综合网| av.在线天堂| 成人性生交大片免费视频hd| 免费看a级黄色片| 中文在线观看免费www的网站| 免费看美女性在线毛片视频| 麻豆久久精品国产亚洲av| 国产精品伦人一区二区| 国产成人福利小说| 看十八女毛片水多多多| 韩国av在线不卡| 爱豆传媒免费全集在线观看| 熟妇人妻久久中文字幕3abv| 在线免费十八禁| 婷婷六月久久综合丁香| 国产伦理片在线播放av一区 | 成人亚洲欧美一区二区av| 美女高潮的动态| 国产亚洲91精品色在线| 国产白丝娇喘喷水9色精品| 久久精品夜色国产| 久久精品国产清高在天天线| 久久精品国产亚洲av涩爱 | eeuss影院久久| a级一级毛片免费在线观看| 亚洲精品久久国产高清桃花| 亚洲国产精品sss在线观看| 欧美最黄视频在线播放免费| 色播亚洲综合网| av在线观看视频网站免费| 国产高清三级在线| 欧美zozozo另类| 午夜福利在线在线| 欧美一级a爱片免费观看看| 少妇猛男粗大的猛烈进出视频 | 又爽又黄a免费视频| 午夜亚洲福利在线播放| 天天躁夜夜躁狠狠久久av| 国产大屁股一区二区在线视频| а√天堂www在线а√下载| 91午夜精品亚洲一区二区三区| 最近最新中文字幕大全电影3| av在线播放精品| 国内少妇人妻偷人精品xxx网站| 天堂影院成人在线观看| а√天堂www在线а√下载| 此物有八面人人有两片| 高清在线视频一区二区三区 | 男插女下体视频免费在线播放| 看非洲黑人一级黄片|