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5-A z a-C d R 5-a z a-2'-d e o x y c y t y d i n e 5-氮[雜]-2'-脫氧胞苷5-F U 5-f l u o r o u r a c i l 5-氟尿嘧啶A A V a d e n o-a s s o c i a t e d v i r u s 腺相關(guān)病毒A D C C a n t i b o d y d e p e n d e n t c e l l m e d i a t e d c y t o t o x i c i t y 抗體依賴細胞介導(dǎo)的細胞毒作用A D R a d v e r s e d r u g r e a c t i o n 藥物不良反應(yīng)A F P a l p h a-f e t o p r o t e i n 甲胎蛋白A I D S a c q u i r e d i m m u n o d e f i c i e n c y s y n d r o m e 獲得性免疫缺陷綜合征(艾滋病)A L L a c u t e l y m p h o i d l e u k e m i a 急性淋巴細胞白血病A M L a c u t e m y e l o b l a s t i c l e u k e m i a 急性粒細胞白血病A P C a n t i g e n p r e s e n t i n g c e l l 抗原提呈細胞A T C C A m e r i c a n T y p e C u l t u r e C o l l e c t i o n 美國模式培養(yǎng)物保藏所B c l-2 B c e l l l y m p h o m a-2 B細胞淋巴瘤2 b F G F b a s i c f i b r o b l a s t g r o w t h f a c t o r 堿性成纖維細胞生長因子C A R c h i m e r i c a n t i g e n r e c e p t o r 嵌合抗原受體C A R-T c h i m e r i c a n t i g e n r e c e p t o r g e n e-m o d i f i e d T l y m p h o c y t e 嵌合抗原受體基因修飾T淋巴細胞C D c l a s t e r o f d i f f e r e n t i a t i o n 白細胞分化抗原群C D K c y c l i n-d e p e n d e n t k i n a s e 周期蛋白依賴性激酶C E A c a r c i n o e m b r y o n i e a n t i g e n 癌胚抗原C F U c o l o n y-f o r m i n g u n i t 集落形成單位c i r c R N A c i r c u l a r R N A 環(huán)狀R N A C I K c y t o k i n e i n d u c e d k i l l e r c e l l 細胞因子誘導(dǎo)的殺傷細胞C M L c h r o n i c m y e l o i d l e u k e m i a 慢性粒細胞白血病C R c o m p l e t e r e s p o n s e 完全緩解C R I S P R-C a s c l u s t e r e d r e g u l a r l y i n t e r s p a c e d s h o r t p a l i n d r o m i c r e p e a t-c l u s t e r e d 成簇規(guī)律間隔短回文重復(fù)系統(tǒng)r e g u l a r l y i n t e r s p a c e d s h o r t p a l i n d r o m i c r e p e a t s a s s o c i a t e d s y s t e m C S C c a n c e r s t e m c e l l腫瘤干細胞C S F c o l o n y-s t i m u l a t i n g f a c t o r 集落刺激因子C T C c i r c u l a t i n g t u m o r c e l l 循環(huán)腫瘤細胞C T L c y t o t o x i c T l y m p h o c y t e 細胞毒性T淋巴細胞C T L A-4 c y t o t o x i c T l y m p h o c y t e a n t i g e n-4 細胞毒性T淋巴細胞抗原-4 C T X c y c l o p h o s p h a m i d e 環(huán)磷酰胺C X C R 4 C-X-C m o t i f c h e m o k i n e r e c e p t o r 4 C X C類趨化因子受體4 D C d e n d r i t i c c e l l 樹突狀細胞D C R d i s e a s e c o n t r o l r a t e 疾病控制率D F S d i s e a s e f r e e s u r v i v a l 無病生存期D R d e a t h r e c e p t o r 死亡受體D R F S d i s t a n t r e c u r r e n c e f r e e s u r v i v a l 無遠處復(fù)發(fā)生存D N M T D N A m e t h y l t r a n s f e r a s e D N A甲基轉(zhuǎn)移酶E B(E t B r) e t h i d i u m b r o m i d e 溴化乙錠E B V E p s t e i n-B a r r v i r u s E B病毒E C M e x t r a c e l l u l a r m a t r i x 細胞外基質(zhì)E G F/-R e p i d e r m a l g r o w t h f a c t o r/-r e c e p t o r 表皮生長因子/-受體E L I S A e n z y m e-l i n k e d i m m u n o s o r b e n t a s s a y 酶聯(lián)免疫吸附測定E M T e p i t h e l i a l-m e s e n c h y m a l t r a n s i t i o n 上皮間質(zhì)轉(zhuǎn)化

ER estrogen receptor 雌激素受體ERK extracellular signal-regulated kinase/extra- 細胞外信號調(diào)節(jié)激酶/細胞外蛋白cellular regulated protein kinase 調(diào)節(jié)激酶ESC embryonic stem cell 胚胎干細胞ESCC esophageal squamous cell carcinoma 食管鱗狀細胞癌FACS fluorescence activated cell sorting 熒光激活細胞分選術(shù)FADD Fas-associated with death protein domain Fas相關(guān)死亡域蛋白FAK focal adhesion kinase 黏著斑激酶FAP focal adhesion plaque 黏著斑FCM flow cytometry/flow cytometer 流式細胞術(shù)/流式細胞儀FDA Food and DrugAministration 食品藥品管理局(美國)FGF/-R fibroblast growth factor/-receptor 成纖維細胞生長因子/-受體FISH fluorescence in situ hybridization 熒光原位雜交FITC fluorescein isothiocyanate 異硫氰酸熒光素FLI1 Friend leukemia virus integration 1 Friend白血病病毒插入位點1 GFP green fluorescent protein 綠色熒光蛋白G-CSF granulocyte colony-stimulating factor 粒細胞集落刺激因子GM-CSF granulocyte-macrophage colony-stimulating factor 粒細胞-巨噬細胞集落刺激因子GVHD graft versus host disease 移植物抗宿主病HCC hepatocellular carcinoma 肝細胞癌HDAC histone deacetylase 組蛋白去乙?；窰-E stain hematoxylin and eosin staining 蘇木精-伊紅染色HER2 human epidermal growth factor receptor 2 人表皮生長因子受體2 HGF hematopoietic growth factor 造血生長因子HGF/-R hepatocyte growth factor/-receptor 肝細胞生長因子/-受體HIF hypoxia-inducible factor 缺氧誘導(dǎo)因子HIV human immunodeficiency virus 人類免疫缺陷病毒HL Hodgkin lymphoma 霍奇金淋巴瘤HLA human leukocyte antigen 人白細胞抗原HMGB1 high mobility group box 1 高遷移率族蛋白1 HPLC high performance liquid chromatography 高效液相層析色譜HPV human papilloma virus 人乳頭狀瘤病毒HRP horseradish peroxidase 辣根過氧化物酶HSC hematopoietic stem cell 造血干細胞HSP heat shock protein 熱激蛋白HSV herpes simplex virus 單純皰疹病毒HUVEC human umbilican vein endothelial cell 人臍靜脈內(nèi)皮細胞ICAM intercellular adhesion molecule 細胞間黏附分子IFN interferon 干擾素IGF/-R insulin-like growth factor/-receptor 胰島素樣生長因子/-受體IHC immunohistochemistry 免疫組織化學(xué)IL interleukin 白細胞介素IMiD immunomodulatory drug 免疫調(diào)節(jié)藥物ISH in situ hybridization 原位雜交JNK c-Jun N-terminal kinase c-Jun氨基末端激酶KAR killer activation receptor 殺傷細胞激活受體KEGG Kyoto Encyclopedia of Genes and Genomes 京都基因與基因組百科全書KIR killer inhibitory receptor 殺傷細胞抑制受體KPS Karnofsky performance status 卡氏（Karnofsky）功能狀態(tài)評分LAG3 lymphocyte-activation gene 3 淋巴細胞活化基因3 LAK lymphokine-activated killer cell 淋巴因子激活的殺傷細胞

LDH lactate dehydrogenase 乳酸脫氫酶lncRNA long non-coding RNA 長鏈非編碼RNA LR local recurrence 局部復(fù)發(fā)LPS lipopolysaccharide 脂多糖LRP lung resistance-related protein 肺耐藥相關(guān)蛋白LSCM laser scanning confocal microscope 激光掃描共聚焦顯微鏡LTR long terminal repeat 長末端重復(fù)序列MAGE melanoma antigen 黑色素瘤抗原MAPK mitogen-activated protein kinase 促分裂原活化蛋白激酶MDR multidurg resistance 多藥耐藥MDSC myeloid-derived suppressor cell 髓源性抑制細胞MHC major histocompatibility complex 主要組織相容性復(fù)合體miRNA microRNA 微小RNA MLR mixed lymphocyte reaction 混合淋巴細胞反應(yīng)MM multiple myeloma 多發(fā)性骨髓瘤MMP matrix metalloproteinase 基質(zhì)金屬蛋白酶MSC mesenchymal stem cell 間質(zhì)干細胞MSI microsatellite instability 微衛(wèi)星不穩(wěn)定性MST median survival time 中位生存時間MTD maximum tolerate dose 最大耐受劑量mtDNA mitochondrial DNA 線粒體DNA MTKI multi-target tyrosine kinase inhibitor 多靶點酪氨酸激酶抑制劑mTOR mammalian target of rapamycin 哺乳動物雷帕霉素靶蛋白MTT thiazolyl blue 噻唑藍MVD microvessel density 微血管密度Mφ cell macrophage cell 巨噬細胞NF-κB nuclear factor-κB 核因子κB NGF/-R nerve growth factor/-receptor 神經(jīng)生長因子/-受體NHL non-Hodgkin lymphoma 非霍奇金淋巴瘤NKG2A natural killer group 2 memberA 自然殺傷細胞2族成員A NKT cell natural killer T cell 自然殺傷T細胞NK cell natural killer cell 自然殺傷細胞NOS nitric oxide synthase 一氧化氮合酶NSCLC non-small cell lung cancer 非小細胞肺癌ORR objective response rate,overall response rate 客觀有效率,總有效率OS overall survival 總生存期PAGE polyacrylamide gel eletrophoresis 聚丙烯酰胺凝膠電泳PBMC peripheral blood mononuclear cell 外周血單個核細胞PCR polymerase chain reaction 聚合酶鏈式反應(yīng)PD progressive disease 疾病進展PD-1 programmed death-1 程序性死亡受體-1 PD-L1 programmed death ligand-1 程序性死亡受體配體-1 PDGF/-R platelet derived growth factor/-receptor 血小板衍生生長因子/受體PFS progression free survival 無進展生存期P-gp P-glycoprotein(permeability-glycoprotein) P-糖蛋白（滲透性糖蛋白）PI propidium iodide 碘化丙啶PI3K phosphatidylinositol 3-hydroxy kinase 磷脂酰肌醇-3-羥基激酶PIP3 phosphtidylinositol(3,4,5)-trisphosphate 磷脂酰肌醇(3,4,5)三磷酸PKA proteinkinaseA 蛋白激酶A PKC proteinkinase C 蛋白激酶C PLC phospholipase C 磷酯酶C PR partial remission 部分緩解PRR pattern recognition receptor 模式識別受體PSA prostate specific antigen 前列腺特異抗原

PSMA prostate specific membrane antigen 前列腺特異性膜抗原PTEN phosphatase and tensin homology deleted on chromosome ten 10號染色體缺失的磷酸酶和張力蛋白同源物PTK protein tyrosine kinase 蛋白酪氨酸激酶QOL quality of life 生活質(zhì)量qPCR Real-time quantitative PCR 實時(熒光)定量PCR RCC renal cell carcinoma 腎細胞癌RCT randomized controlled trial 隨機對照試驗RFS relapse free survival 無復(fù)發(fā)生存ROC receiver operator characteristic curve 受試者工作特征曲線RR response rate 反應(yīng)(有效)率RT-PCR reverse transcription-PCR 逆轉(zhuǎn)錄聚合酶鏈式反應(yīng)RT-qPCR reverse transcription Real-time quantitative PCR 實時(熒光)定量逆轉(zhuǎn)錄聚合酶鏈式反應(yīng)SA streptavidin 鏈霉親和素ScFv single chain Fv 單鏈抗體SCID severe combined immune deficient disease 重癥聯(lián)合免疫缺陷病SD stable disease 疾病穩(wěn)定SDS sodium dodecyl sulfate 十二烷基硫酸鈉SNP single nucleotide polymorphism 單核苷酸多態(tài)性STAT signal transducer and activator of transcription 信號轉(zhuǎn)導(dǎo)及轉(zhuǎn)錄激活因子TAA tumor-associated antigen 腫瘤相關(guān)抗原TAK tumor antigen-activated killer cell 腫瘤抗原激活殺傷細胞TAF tumor angiogenesis factor 腫瘤血管生成因子TAIT tumor adoptive immume therapy 腫瘤過繼免疫治療TAM tumor-associated macrophage 腫瘤相關(guān)巨噬細胞TCR T cell receptor T淋巴細胞受體TCR-T T cell receptor gene-modified T lymphocyte T淋巴細胞受體基因修飾T淋巴細胞TGF transforming growth factor 轉(zhuǎn)化生長因子Th helper T cell 輔助性T淋巴細胞Treg cell regulatory T cell 調(diào)節(jié)性T淋巴細胞Ts suppressor T cell 抑制性T淋巴細胞TIL tumor-infiltrating lymphocyte 腫瘤浸潤淋巴細胞TIM-3 T cell immunoglobulin and mucin-containing protein-3 T細胞免疫球蛋白黏蛋白分子3 TKI tyroline kinase inhibitor 酪氨酸激酶抑制劑TLR Toll-like receptor Toll樣受體TNF tumor necrosis factor 腫瘤壞死因子TNM Tumor Node Metastasis 國際腫瘤分期標準[根據(jù)腫瘤(T)、淋巴結(jié)(N)及轉(zhuǎn)移(M)情況的癌癥分類法]TPA tumor polypeptide antigen 腫瘤多肽抗原TRAIL TNF-related apoptosis-inducing ligand 腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體TSA tumor-specific antigen 腫瘤特異性抗原TSTA tumor specific transplantation antigen 腫瘤特異性移植抗原TTF time to treatment failure 治療失敗時間TTP tumor to progression 腫瘤進展UTR untranslated region 非翻譯區(qū)VEGF/-R vascular endothelial growth factor/-receptor 血管內(nèi)皮生細胞長因子/-受體VP16 etoposide 依托泊苷WB Western blotting Western印跡,蛋白質(zhì)印跡法WHO World Health Organization 世界衛(wèi)生組織ZNF zinc finger protein 鋅指蛋白