致謝

科研工作的順利完成離不開他人的幫助，在正文的最后應(yīng)向?qū)Ρ狙芯刻峁┻^幫助的人致以謝意。致謝的對象包括：對研究工作提出指導(dǎo)性建議者，論文審閱者，資料提供者，技術(shù)協(xié)作者，幫助統(tǒng)計(jì)者，為本文繪制圖表者，提供樣品、材料、設(shè)備以及其他方便者。

致謝必須實(shí)事求是，應(yīng)防止剽竊掠美之嫌，也勿強(qiáng)加于人，如未經(jīng)允許寫上專家、教授的名字，以示審閱來抬高自己。致謝一般要說明被謝者的工作的內(nèi)容，如“技術(shù)指導(dǎo)”、“收集資料” 、“提供資料”等。

CT perfusion imaging for predicting tiny lymph nodes metastasis of squamous cell carcinoma in cervix after neoadjuvant chemotherapy

YINLiang,LEIJunqiang*,GUOShunlin,ZHAIYanan,GUOQihong

(DepartmentofRadiology,theFirstHospitalofLanzhouUniversity,Lanzhou730000,China)

Objective To explore the application value of CT perfusion imaging for predicting the tiny lymph nodes metastasis and micrometastasis of squamous cell carcinoma in cervix after neoadjuvant chemotherapy. Methods The clinical data and CT perfusion parameters of 46 patients with cervical squamous cell carcinoma who underwent neoadjuvant chemotherapy followed by surgery were enrolled in the study. Based on the surgical pathology findings and short-term follow up, the cases were divided into without tiny lymph nodes metastasis (short axle diameter of lymph nodes<10 mm) group (n=32) and with tiny lymph nodes metastasis group (n=14). All perfusion data were analyzed retrospectively and the diagnostic value were investigated. Results Blood flow (BF), blood volume (BV) and the maximum diameter of tumor per-chemotherapy in with tiny lymph nodes metastasis group were higher than those in without tiny lymph nodes metastasis group (allP<0.05). The differences of the maximum diameter of tumor after chemotherapy, permeability, time to peak (TTP) between two groups were not statistically significant (allP>0.05). MultivariateLogisticregression analysis showed BF and the maximum diameter of tumor per-chemotherapy were independent predictors of the tiny lymph nodes metastasis in cervix after neoadjuvant chemotherapy. ROC showed BF (AUC=0.86,P<0.001, 95%CI [0.75, 0.96]) had higher predictive value than maximum diameter of tumor per-chemotherapy (AUC=0.70,P=0.02, 95%CI [0.54,0.88]). Conclusion CT perfusion imaging shows the significant predictive value for the tiny lymph nodes metastasis of squamous cell carcinoma in cervix after neoadjuvant chemotherapy.

Uterine neoplasms; Tomography, X-ray computed; Chemotherapy, adjuvant; Lymphatic metastasis

10.13929/j.1003-3289.201610024