張永輝+汪欣虹+姜慧騰

【摘要】 目的：分析糖尿病性牙周炎患者單用牙周基礎(chǔ)治療與聯(lián)合替硝唑膠囊治療的臨床效果。方法：選取2012年1月-2016年12月本院收治的確診為糖尿病性牙周炎的患者82例，按照隨機(jī)數(shù)字表法將其分為對照組和觀察組，各41例。對照組予以牙周基礎(chǔ)治療，觀察組在對照組基礎(chǔ)上聯(lián)合予以替硝唑膠囊治療。對比兩組治療前后的菌斑指數(shù)、齦溝出血指數(shù)、附著喪失、松動度檢出差異，并就治療期間兩組的不良反應(yīng)發(fā)生情況進(jìn)行統(tǒng)計觀察。結(jié)果：治療前，兩組菌斑指數(shù)、齦溝出血指數(shù)、附著喪失、松動度比較，差異均無統(tǒng)計學(xué)意義（P>0.05）；治療后，觀察組菌斑指數(shù)、齦溝出血指數(shù)、附著喪失、松動度分別為（0.8±0.1）、（0.7±0.1）、（1.8±0.3）mm、（1.0±0.2）mm，均顯著低于對照組（P<0.05）；兩組不良反應(yīng)總發(fā)生率比較，差異無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論：糖尿病性牙周炎患者在牙周基礎(chǔ)治療同時聯(lián)合替硝唑膠囊治療可進(jìn)一步鞏固療效，改善牙周炎相關(guān)癥狀，且無明顯不良反應(yīng)，聯(lián)合用藥安全可靠，值得在臨床實踐中進(jìn)一步推廣。

【關(guān)鍵詞】 糖尿病； 牙周炎； 替硝唑膠囊； 療效

【Abstract】 Objective：To analyze the clinical effect of single periodontal basic therapy and combined with Tinidazole Capsules in treatment of diabetic periodontitis.Method：82 cases of diabetic periodontitis from January 2012 to December 2016 in our hospital were selected，according to random number table，they were divided into control group and observation group，41 cases in each group.The control group was treated with periodontal basic therapy，and observation group was treated with Tinidazole Capsules on basis of control group.The plaque index，sulcus bleeding index，attachment loss and looseness were compared between two groups before and after treatment，and the incidence of adverse reactions of two groups during treatment were statistically observed.Result：Before treatment，the plaque index，sulcus bleeding index，attachment loss and looseness of two groups were compared，the difference were not statistically significant（P>0.05）；after treatment，the plaque index，sulcus bleeding index，attachment loss and looseness of observation group were（0.8±0.1），（0.7±0.1），（1.8±0.3） mm，（1.0±0.2） mm respectively，which were significantly lower than those of control group（P<0.05）；the total incidence of adverse reactions of two groups were compared，the difference was not statistically significant（P>0.05）.Conclusion：Periodontal basic therapy and combined with Tinidazole Capsules in treatment of diabetic periodontitis can further consolidate the curative effect，improve periodontitis related symptoms，and no obvious adverse reactions，combined medication is safe and reliable，and is worthy of further promotion in clinical practice.

【Key words】 Diabetes； Periodontitis； Tinidazole Capsules； Efficacy

First-authors address：The Third Peoples Hospital of Jingdezhen，Jingdezhen 333000，China

doi：10.3969/j.issn.1674-4985.2017.33.013

在社會發(fā)展水平不斷提升與加快的背景下，大眾飲食結(jié)構(gòu)進(jìn)一步調(diào)整，生活方式也發(fā)生了明顯的轉(zhuǎn)變[1]。在大量因素的作用下，糖尿病臨床發(fā)病率正逐年上升。既往有關(guān)報道中指出，糖尿病與牙周炎具有非常密切的雙星關(guān)系，發(fā)病危險性高度一致，即糖尿病是導(dǎo)致牙周炎發(fā)病率上升的獨(dú)立危險性因素[2-3]。既往研究證實，糖尿病會造成牙周炎病情加重，發(fā)病率上升，而糖尿病同時也是導(dǎo)致牙周炎形成發(fā)展的最主要原因之一[4-6]。對于糖尿病性牙周炎患者而言，若臨床診治不及時，可能導(dǎo)致患者出現(xiàn)一系列并發(fā)癥，如糖尿病腎病、糖尿病足、心血管疾病等[7]。通過對糖尿病性牙周炎患者牙周炎癥的科學(xué)治療與干預(yù)，能夠幫助患者控制血糖水平，臨床價值備受醫(yī)務(wù)人員關(guān)注與重視。為分析糖尿病性牙周炎患者單用牙周基礎(chǔ)治療與聯(lián)合替硝唑膠囊治療的臨床療效，本研究選取2012年endprint