陳燕波:糖化血紅蛋白、空腹血糖、尿微量白蛋白檢測對糖尿病腎病患者的意義分析

陳燕波

DOI：10.16658/j.cnki.1672-4062.2020.20.065

[摘要] 目的 探索糖化血紅蛋白（HbA1c）、空腹血糖（FBG）、尿微量白蛋白（mALB）在糖尿病腎病患者診療中的應(yīng)用價值。 方法 于該院2018年10月—2019年11月收治的糖尿病腎病患者中選出76例為DN組，并選取同期收治的單純糖尿病患者中選出76例為糖尿病組，選取同期體檢的健康人76名為對照組，均進行糖化血紅蛋白、空腹血糖和尿微量白蛋白檢測。 結(jié)果 3組對象的HbA1c、FBG、mALB水平比較：對照組<糖尿病組9.0%患者的DN檢出率為71.43%，差異有統(tǒng)計學(xué)意義（P<0.001）;FBG<7.8 mmol/L患者的DN檢出率28.89%，F(xiàn)BG在7.8～11.0 mmol/L患者的DN檢出率50.0%，F(xiàn)BG>11.0 mmol/L患者的DN檢出率為74.36%，差異有統(tǒng)計學(xué)意義（P<0.001）。 結(jié)論 糖化血紅蛋白、空腹血糖、尿微量白蛋白聯(lián)合檢驗在糖尿病腎病患者診斷中應(yīng)用有助于早期檢出糖尿病腎病，指導(dǎo)臨床治療。

[關(guān)鍵詞] 糖化血紅蛋白;空腹血糖;尿微量白蛋白;糖尿病腎病

[中圖分類號] R587.2? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1672-4062（2020）10（b）-0065-03

Significance Analysis of Glycosylated Hemoglobin， Fasting Blood Glucose and Urine Microalbumin in Patients with Diabetic Nephropathy

CHEN Yan-bo

Department of Laboratory Medicine， Puning People's Hospital， Puning， Guangdong Province， 515300 China

[Abstract] Objective To explore the application value of glycosylated hemoglobin （HbA1c）， fasting blood glucose （FBG） and urine microalbumin （mALB） in the diagnosis and treatment of diabetic nephropathy. Methods From October 2018 to November 2019 in the hospital， 76 patients with diabetic nephropathy were selected as the DN group， and 76 patients with simple diabetes admitted in the same period were selected as the diabetes group， and healthy people who had physical examinations during the same period were selected 76 people were in the control group， all were tested for glycosylated hemoglobin， fasting blood glucose and urine microalbumin. Results Comparison of HbA1c， FBG and mALB levels of the three groups of subjects： control group <diabetes group <DN group， the difference between the two comparisons was statistically significant（P <0.001）; the detection rate of DN in patients with HbA1c level <6.0% was 23.08%. The detection rate of DN in patients with HbA1c level between 6.5%～9.0% was 52.11%， and the detection rate of DN in patients with HbA1c level>9.0% was 71.43%， the difference was statistically significant（P<0.001）; FBG<7.8 mmol/L patients' detection rate of DN was 28.89%， the detection rate of DN in patients with FBG between 7.8 and 11.0 mmol/L was 50.0%， and the detection rate of DN in patients with FBG>11.0 mmol/L was 74.36%. The difference was statistically significant（P<0.001）. Conclusion The combined test of glycosylated hemoglobin， fasting blood glucose and urine microalbumin in the diagnosis of diabetic nephropathy is helpful for early detection of diabetic nephropathy and guide clinical treatment.