段恩奎 雷曉華
摘 要:隨著空間生命科學研究的發(fā)展,人們將細胞、組織培養(yǎng)技術與微重力環(huán)境相結合產生了組織工程研究的一個新領域—微重力組織工程。模擬太空微重力條件下細胞培養(yǎng)和組織構建研究表明,微重力環(huán)境有利于細胞的三維生長,形成具有功能的組織樣結構,培養(yǎng)后的三維組織無論從形態(tài)上還是基因表達上都更接近于正常的機體機體組織。這種微重力對細胞的作用效應,將可能為未來組織工程和再生醫(yī)學研究提供一條新途徑。
關鍵詞:微重力 生物反應器 細胞培養(yǎng) 組織工程
Abstract:Along with the development of space biology, the technique of tissue and cell culture under microgravity is becoming a new research filed, which has been known as microgravity tissue engineering. The study of microgravity or simulated microgravity on cells and tissues culture indicated that microgravity could offer a special effects on forming three-dimension (3-D) tissue structure and functional tissues. The 3-D tissue constructs generated on microgravity conditions exhibit more similar phenotypes in either morphous or gene expression profiles to those in normal tissues in vivo.
Key Words:Microgravity;Bioreactor;Cell culture;Tissue engineering
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