• 
    

    
    

      99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

      德?tīng)柋吧抽T菌的研究進(jìn)展

      2017-08-01 00:14:40鄭慧娟潘志明焦新安
      關(guān)鍵詞:人獸德?tīng)?/a>沙門

      鄭慧娟,潘志明,焦新安

      ?

      德?tīng)柋吧抽T菌的研究進(jìn)展

      鄭慧娟,潘志明,焦新安

      德?tīng)柋吧抽T菌是重要的人獸共患病原菌,可引起人食物中毒和敗血癥等癥狀,而且對(duì)牲畜的繁殖及健康帶來(lái)嚴(yán)重威脅。本文就德?tīng)柋吧抽T菌的流行現(xiàn)狀、基因組學(xué)及致病機(jī)制等方面的研究進(jìn)行總結(jié),以期為該菌的防治提供指導(dǎo)。

      德?tīng)柋吧抽T菌;流行現(xiàn)狀;基因組學(xué);致病機(jī)制

      Funded by the National Key Research and Development Program Special Project (No.2016YFD0501607), Agroscientific Research in the Public Interest (No.201403054), the National Natural Science Foundation of China (Nos. 31320103907 and 31230070), the Research and Development Program of Jiangsu (BE2015343), the "six Talent Peaks Program" of Jiangsu Province (No.NY-028), the Yangzhou University Science and Technology Innovation Team, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

      沙門菌是引起世界范圍內(nèi)人類食源性疾病的首要因素[1]。絕大多數(shù)沙門菌對(duì)人和動(dòng)物有致病性,具有重要的公共衛(wèi)生意義[2]。近年來(lái)在豬肉生產(chǎn)鏈中德?tīng)柋吧抽T菌的分離率逐漸趨于首位,其在健康人群的攜帶率也位于前列。本文綜述了德?tīng)柋吧抽T菌在流行現(xiàn)狀、基因組學(xué)和致病機(jī)制等方面的研究進(jìn)展,以期為德?tīng)柋吧抽T菌的防治提供理論依據(jù)。

      1 德?tīng)柋吧抽T菌流行現(xiàn)狀

      1.1 流行病學(xué)調(diào)查 生豬屠宰場(chǎng)及豬肉的流行病學(xué)研究發(fā)現(xiàn),德?tīng)柋吧抽T菌已成為優(yōu)勢(shì)血清型之一[3-5]。德?tīng)柋吧抽T菌是1923年P(guān)eckham在引起食物中毒的豬肉餅中首次分離到的[6]。它在1923-1944年間引起英格蘭和威爾士11起暴發(fā)性的食物中毒,1946年澳大利亞的一家醫(yī)院也暴發(fā)了由德?tīng)柋吧抽T菌引起的嬰兒腹瀉,其中68個(gè)嬰兒發(fā)病,10例死亡[7]。美國(guó)每年約有上百萬(wàn)人因食用沙門菌污染的食品而引起腸熱癥、胃腸炎和敗血癥等疾病[8]。德?tīng)柋吧抽T菌主要在豬肉中分離到[9],沙門菌污染的豬肉是導(dǎo)致人感染沙門菌的第二大來(lái)源,歐洲26個(gè)國(guó)家豬源沙門菌的主要血清型分別是鼠傷寒沙門菌、德?tīng)柋吧抽T菌和腸炎沙門菌,而且德?tīng)柋吧抽T菌分離率有超越鼠傷寒沙門菌的趨勢(shì)[10]。在2006-2007年間,歐盟對(duì)其25個(gè)成員國(guó)及挪威生豬屠宰場(chǎng)淋巴結(jié)樣品及13個(gè)成員國(guó)生豬屠宰場(chǎng)豬胴體擦拭樣品沙門菌的污染狀況進(jìn)行流行病學(xué)分析,發(fā)現(xiàn)沙門菌污染率分別為10.3%和8.3%;淋巴結(jié)樣品沙門菌分離株血清型中,德?tīng)柋吧抽T菌分離率為24.3%,位居第二;而胴體來(lái)源沙門菌2個(gè)主要血清型分別為鼠傷寒沙門菌占49.4%,德?tīng)柋吧抽T菌占24.3%[11]。近年來(lái),德?tīng)柋吧抽T菌引起的沙門菌病逐漸上升[12],這不僅對(duì)人的健康造成了嚴(yán)重的威脅,同時(shí)影響了經(jīng)濟(jì)的發(fā)展,所以應(yīng)該引起人們對(duì)德?tīng)柋吧抽T菌的重視。

      在我國(guó)德?tīng)柋吧抽T菌也逐漸成為最優(yōu)勢(shì)血清型。李昱辰等[13]和蔡銀強(qiáng)等[14]對(duì)江蘇省屠宰場(chǎng)及農(nóng)貿(mào)市場(chǎng)豬肉樣品沙門菌的污染情況進(jìn)行調(diào)查發(fā)現(xiàn)德?tīng)柋吧抽T菌的分離率均占首位。1990年山東一家醫(yī)院內(nèi)暴發(fā)了由德?tīng)柋吧抽T菌引起的嬰幼兒腹瀉,其中有3名患者并發(fā)敗血癥[15]。2006年通過(guò)對(duì)武漢同濟(jì)醫(yī)院0~3歲孩子的3 746份門診腹瀉樣本沙門菌的分離鑒定發(fā)現(xiàn),德?tīng)柋吧抽T菌的分離率占首位[16]。從這些數(shù)據(jù)可以看出德?tīng)柋吧抽T菌在國(guó)內(nèi)食品中流行比較嚴(yán)重,尤其是豬肉樣品,而中國(guó)作為豬肉生產(chǎn)和消費(fèi)大國(guó),應(yīng)加強(qiáng)對(duì)德?tīng)柋吧抽T菌的監(jiān)測(cè)。目前,發(fā)達(dá)國(guó)家正逐步建立食源性致病菌監(jiān)測(cè)網(wǎng)和同源性分析網(wǎng)等來(lái)應(yīng)對(duì)食源性疾病的暴發(fā)和新病原菌的出現(xiàn),世界衛(wèi)生組織(World Health Organization, WHO)于2000年建立了全球沙門菌監(jiān)測(cè)網(wǎng)(World Health Organization Global Salmonella Survey, WHO GSS)[17]。

      1.2 分子流行病學(xué)研究 多位點(diǎn)序列分型(Multilocus sequence typing, MLST)通過(guò)對(duì)細(xì)菌多個(gè)管家基因核酸序列的測(cè)定從而對(duì)細(xì)菌進(jìn)行分型,此分型方法操作簡(jiǎn)單,重復(fù)性好[18],而且Sukhnanand等[19]研究發(fā)現(xiàn)沙門菌ST型與其血清型之間有很好的對(duì)應(yīng)關(guān)系,可以對(duì)沙門菌血清型進(jìn)行預(yù)測(cè)。通過(guò)查閱沙門菌MLST數(shù)據(jù)庫(kù) (http://mlst.warwick.ac.uk/mlst/dbs/Senterica/Get

      TableInfo_html)發(fā)現(xiàn)德?tīng)柋吧抽T菌一共有13種ST型,分別為ST15、ST39、ST40、ST71、ST72、ST678、ST682、ST683、ST695、ST774、ST813、ST1326、ST1585,而ST40沙門菌大多分離于豬及豬肉中,與此同時(shí)引起了大量的人沙門菌病。而目前我國(guó)主要有ST40和ST71兩種ST型,其中以ST40為主,而ST71在近幾年才開始出現(xiàn)[13-14]。在國(guó)外德?tīng)柋吧抽T菌ST型種類比較豐富,比如丹麥德?tīng)柋吧抽T菌ST型有6種,分別為ST39、ST40、ST71、ST678、ST682、ST683[20],在德國(guó)德?tīng)柋吧抽T菌ST型有5種,ST39、ST40、ST71、ST682、ST774,其中ST39是分離率最高的一種ST型,而ST774是新發(fā)現(xiàn)的一種ST型[21]。從以上數(shù)據(jù)可以看出德?tīng)柋吧抽T菌ST型比較豐富,但是由于管家基因相對(duì)比較保守,其在區(qū)分高度關(guān)聯(lián)的菌株時(shí)仍存在一定的局限性,無(wú)法區(qū)分各ST型之間的親緣關(guān)系,因此需要分辨力更高的分型方法。

      2 德?tīng)柋吧抽T菌基因組學(xué)研究

      根據(jù)GenBank公布的序列,目前已有12株德?tīng)柋吧抽T菌完成了基因組測(cè)序,這推動(dòng)了德?tīng)柋吧抽T菌基因組的研究,加深了對(duì)其致病機(jī)理的認(rèn)識(shí),為德?tīng)柋吧抽T菌的防控研究奠定了基礎(chǔ)。德?tīng)柋吧抽T菌主要在豬和豬肉上分離到,這是否說(shuō)明德?tīng)柋吧抽T菌對(duì)豬有宿主適應(yīng)性還有待研究。Hayward等[22]對(duì)兩株豬源德?tīng)柋吧抽T菌D1、D2進(jìn)行全基因組測(cè)序,通過(guò)序列比對(duì)發(fā)現(xiàn)德?tīng)柋吧抽T菌基因組中存在一個(gè)新的毒力島(SPI-23),長(zhǎng)37 Kb,42個(gè)開放閱讀框,除此之外德?tīng)柋吧抽T菌的SPI-2, SPI-4與豬霍亂沙門菌SC-B67在基因組序列上完全一致,而SPI-18與傷寒沙門菌CT-18在基因組序列上完全一致。但是德?tīng)柋吧抽T菌基因組中缺失10個(gè)毒力島(SPI-7, SPI-8, SPI-10, SPI-15, SPI-16, SPI-17, SPI-19, SPI-20, SPI-21, SPI-22)。

      細(xì)菌質(zhì)粒是獨(dú)立存在于細(xì)菌染色體DNA之外的遺傳物質(zhì),其具有可獨(dú)立復(fù)制和轉(zhuǎn)錄的能力,而且質(zhì)粒攜帶的基因與宿主菌的表型密切相關(guān)[23]。耐藥質(zhì)粒在選擇性壓力下可以發(fā)生水平轉(zhuǎn)移[24]。在德?tīng)柋吧抽T菌基因組上存在IncL和ColE1兩個(gè)耐β-內(nèi)酰胺類抗生素質(zhì)粒[25-26],Anne Bleicher等[27]研究發(fā)現(xiàn)了德?tīng)柋吧抽T菌4個(gè)新質(zhì)粒(pSD4.0, pSD4.6, pSD5.6, pSD107),而且其基因組上存在的大質(zhì)粒與小質(zhì)粒間可以發(fā)生穩(wěn)定的轉(zhuǎn)移。但是目前有關(guān)德?tīng)柋吧抽T菌質(zhì)粒的數(shù)據(jù)相對(duì)較少,還有許多未知問(wèn)題有待研究。

      3 德?tīng)柋吧抽T菌致病機(jī)制研究

      沙門菌的致病性與入侵非吞噬細(xì)胞的能力、在胞內(nèi)存活的能力、以及在吞噬細(xì)胞內(nèi)復(fù)制和增殖的能力有關(guān)[28]。通過(guò)德?tīng)柋吧抽T菌感染小鼠模型發(fā)現(xiàn)其是低毒力菌株,口服低于2×108CFU(Colony Forming Units)對(duì)小鼠是不致死的,腹腔注射量為5×106CFU(Colony Forming Units)時(shí)死亡率為40%。德?tīng)柋吧抽T菌不僅可在小鼠糞便和尿液中存在5個(gè)月之久,而且其在多個(gè)臟器內(nèi)都可分離到,如心臟、脾臟,小腸、膀胱等[7]。德?tīng)柋吧抽T菌也可引起豬的長(zhǎng)程感染,并且在多個(gè)臟器內(nèi)長(zhǎng)期定植,如扁桃體、回盲淋巴結(jié)、脾臟、空腸、結(jié)腸、盲腸等,這可導(dǎo)致生豬屠宰時(shí)對(duì)豬肉的污染,所以其在豬肉中的分離率居高不下。細(xì)菌引起的免疫應(yīng)答反應(yīng)較弱,這也許是機(jī)體無(wú)法將其快速清除的一個(gè)原因[29]。德?tīng)柋吧抽T菌SPI-23上的potR基因在德?tīng)柋吧抽T菌對(duì)IPEC-J2細(xì)胞的黏附和侵襲有著重要的作用,缺失potR基因后,細(xì)菌對(duì)IPEC-J2細(xì)胞的黏附率和侵襲率顯著下降。當(dāng)細(xì)菌侵襲豬的空腸上皮細(xì)胞時(shí)SPI-23上有9個(gè)基因的表達(dá)量會(huì)上調(diào)(potR,chlR,docB,genE,shaU,dumE,sadZ,tinY,talN),由此可看出這些基因與德?tīng)柋吧抽T菌的致病性密切相關(guān)[9]。德?tīng)柋吧抽T菌感染豬時(shí)往往不會(huì)引起明顯的臨床癥狀,豬只是長(zhǎng)程帶菌成為傳染源,危害整個(gè)群體,而且如果豬群感染其它高致病性病原菌時(shí),其可引起繼發(fā)感染,導(dǎo)致豬的死亡率增加。由于這些低毒力菌株不會(huì)引起明顯的臨床癥狀,容易被忽視,所以對(duì)食品安全的威脅會(huì)更嚴(yán)重。

      4 展 望

      目前對(duì)德?tīng)柋吧抽T菌的研究數(shù)據(jù)還較少,而且細(xì)菌在哺乳動(dòng)物模型中的致病機(jī)制的相關(guān)信息有限,所以這給防治帶來(lái)一定的困難。慶幸的是,現(xiàn)在國(guó)內(nèi)外已經(jīng)對(duì)德?tīng)柋吧抽T菌重視起來(lái),全基因組數(shù)據(jù)也逐漸增多,相信在不久的將來(lái),有關(guān)德?tīng)柋吧抽T菌的致病機(jī)理、免疫應(yīng)答以及分子流行病學(xué)等方面的研究會(huì)取得重大突破。

      [1] Litrup E, Torpdahl M, Malorny B, et al. Association between phylogeny, virulence potential and serovars ofSalmonellaenterica[J]. Infect Genet Evol, 2010, 10(7): 1132-1139. DOI: 10.1016/j.meegid.2010.07.015

      [2] Lu CP. Veterinary microbiology[M]. 4th ed. Beijing: China Agriculture Press, 2001: 107-113. (in Chinese)

      陸承平.獸醫(yī)微生物學(xué)[M].4版.北京:中國(guó)農(nóng)業(yè)出版社,2001:107-113.

      [3] Denis M, Houard E, Fablet A, et al. Distribution of serotypes and genotypes ofSalmonellaentericaspecies in French pig production[J]. Vet Rec, 2013, 173(15). DOI: 10.1136/vr.101901

      [4] Li R, Lai J, Wang Y, et al. Prevalence and characterization ofSalmonellaspecies isolated from pigs, ducks and chickens in Sichuan Province, China[J]. Int J Food Microbiol, 2013, 163(1): 14-18. DOI: 10. 1016/j.ijfoodmicro.2013.01.020

      [5] Arguello H, Carvajal A, Collazos JA, et al. Prevalence and serovars ofSalmonellaenterica on pig carcasses, slaughtered pigs and the environment of four Spanish slaughterhouses[J]. Food Res Int, 2012, 45: 905-912. DOI: 10.1016/j.foodres.2011.04.017

      [6] Peckham CF, Savage WG. An outbreak of pork pie poisoning at Derby[J]. J Hyg (Lond), 1923, 22(1): 69-76. DOI: 10.1017/S0022172400008068

      [7] Mushin R. An outbreak of gastro-enteritis due toSalmonellaDerby[J]. J Hyg (Lond), 1948, 46(2): 151, 154-157. DOI: 10.1017/S0022172400036238

      [8] Scallan E, Hoekstra RM, Angulo FJ, et al. Foodborne illness acquired in the United States-major pathogens[J]. Emerg Infect Dis, 2011, 17(1): 7-15. DOI: 10.3201/eid1701.091101p1

      [9] Hayward MR, AbuOun M, La Ragione RM, et al. SPI-23 of S. Derby: Role in adherence and invasion of porcine tissues[J]. PLoS one, 2014, 9(9): e107857. DOI: 10.1371/journal.pone.0107857

      [10] Pires SM, de Knegt L, Hald T. Estimation of the relative contribution of different food and animal sources to humanSalmonellainfections in the European Union[R]. National Food Institute, 2012, Technical University of Denmark.

      [11] European Food Safety Authority. Task force on zoonoses data collection on the analysis of the baseline survey on the prevalence ofSalmonellain slaughter pigs, in the EU, 2006-2007[R]. EFSA J, 2008, 135: 1-111.DOI:10.2903/j.efsa.2008.1358

      [12] European Food Safety Authority. Analysis of the baseline survey on the prevalence ofSalmonellain holding with breeding pigs, in the EU, 2008 part B: factors associated withSalmonellapen positivity[R]. EFSA J, 2011, 9(7): 1-159.DOI:10.2903/j.efsa.2011.2329

      [13] Li Y, Cai Y, Tao J, et al.Salmonellaisolated from the slaughterhouses and correlation with pork contamination in free market[J]. Food Control, 2016, 59: 591-594, 597-600. DOI: 10.1016/j.foodcont.2015.06.040

      [14] Cai Y, Tao J, Jiao Y, et al. Phenotypic characteristics and genotypic correlation betweenSalmonellaisolates from a slaughterhouse and retail markets in Yangzhou, China[J]. Int J Food Microbiol, 2016, 222: 56-58, 59-64. DOI: 10.1016/j.ijfoodmicro.2016.01.020

      [15] Li JE, Yan M, Liu M, et al. An outbreak investigation of infants and toddlers gastro-enteritis due toSalmonellaDerby in the hospital[J]. Chin J Nosocomiol, 1995(3): 163. (in Chinese)

      李積恩,嚴(yán)銘,劉民,等.德?tīng)柋吧抽T氏菌醫(yī)院內(nèi)嬰幼兒腹瀉暴發(fā)調(diào)查[J].中華醫(yī)院感染學(xué)雜志,1995 (3): 163.

      [16] Cui S, Li J, Sun Z, et al. Characterization ofSalmonellaenterica isolates from infants and toddlers in Wuhan, China[J]. J Antimicrob Chemother, 2009, 63(1): 87-94. DOI: 10.1093/jac/dkn452

      [17] Ran L, Zhang J. Global foodborne pathogenic surveillance and monitoring network[J]. Chin J Food Hyg, 2005, 17(4): F002-F002. (in Chinese)

      冉陸,張靜.全球食源性疾病監(jiān)測(cè)及監(jiān)測(cè)網(wǎng)絡(luò)[J].中國(guó)食品衛(wèi)生雜志,2005,17(4): F002-F002.

      [18] Kotetishvili M, Stine OC, Kreger A, et al. Multilocus sequence typing for characterization of clinical and environmentalSalmonellastrains[J]. J Clin Microbiol, 2002, 40(5): 1626-1635. DOI: 10.1128/JCM.40.5.1626-1635.2002

      [19] Sukhnanand S, Alcaine S, Warnick LD, et al. DNA sequence-based subtyping and evolutionary analysis of selectedSalmonellaenterica serotypes[J]. J Clin Microbiol, 2005, 43(8): 3688-3698. DOI: 10.1128/JCM.43.8.3688-3689.2005

      [20] Litrup E, Torpdahl M, Malorny B, et al. Association between phylogeny, virulence potential and serovars ofSalmonellaenterica[J]. Infect Genet Evol, 2010, 10: 1132-1139. DOI: 10.1016/j.meegid.2010.07.015

      [21] Elisabeth H, Franka H, Erhard T, et al. Diversity ofSalmonellaenterica serovar Derby isolated from pig, pork and humans in Germany[J]. Int JFood Microbiol, 2011, 151: 141-149. DOI: 10.1016/j.ijfoodmicro.2011.08.020

      [22] Hayward MR, Jansen VAA, Woodward MJ. Comparative genomics ofSalmonellaenterica serovars Derby and Mbandaka, two prevalent serovars associated with different livestock species in the UK[J]. BMC Genomics, 2013, 14(1): 1. DOI: 10. 1186/1471-2164-14-365

      [23] Sambrook J. Molecular cloning[M]. 2nd ed. New York: Cold Spring Habor Laboratory Press, 2003: 169-182.

      [24] Bennett PM. Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria[J]. Br J Pharmacol, 2008, 153(S1): S347-S357. DOI: 10.1038/sj.bjp.0707607

      [25] Cloeckaert A, Praud K, Doublet B, et al. Dissemination of an extended-spectrum-β-lactamase blaTEM-52 gene-carrying IncI1 plasmid in variousSalmonellaenterica serovars isolated from poultry and humans in Belgium and France between 2001 and 2005[J]. Antimicrob Agents Chemother, 2007, 51(5): 1872-1875. DOI: 10.1128/AAC. 01514-06

      [26] Vignoli R, Cordeiro NF, García V, et al. New TEM-derived extended-spectrum β-lactamase and its genomic context in plasmids fromSalmonellaenterica serovar Derby isolates from Uruguay[J]. Antimicrob Agents Chemother, 2006, 50(2): 781-784. DOI: 10.1128/AAC.50.2.781-784.2006

      [27] Bleicher A, Sch?fl G, Rosario Rodicio M, et al. The plasmidome of aSalmonellaenterica serovar Derby isolated from pork meat[J]. Plasmid, 2013, 69(3): 202-210. DOI: 10.1016/j.plasmid.2013.01.001

      [28] Dandekar T, Fieselmann A, Fischer E, et al.Salmonella-how a metabolic generalist adopts an intracellular lifestyle during infection[J]. Front Cell Infect Microbiol, 2015, 4: 191. DOI: 10.3389/fcimb.2014.00191

      [29] Matiasovic J, Stepanova H, Kudlackova H, et al. Immune response of pigs toSalmonellaenterica serovar Derby andTyphimuriuminfections[J]. Vet Microbiol, 2014, 170(3): 284-290. DOI: 10.1016/j.vetmic.2014.02.003

      ·消 息·

      歡迎關(guān)注《中國(guó)人獸共患病學(xué)報(bào)》微信公眾平臺(tái)

      中國(guó)人獸共患病學(xué)報(bào)微信公眾平臺(tái)二維碼

      為提升期刊影響力,實(shí)現(xiàn)信息傳播的覆蓋面和效果的最大化,《中國(guó)人獸共患病學(xué)報(bào)》微信公眾平臺(tái)自2014年開通以來(lái),推送人獸共患病相關(guān)資訊、本刊當(dāng)期目錄、中英文摘要、全文鏈接、本刊動(dòng)態(tài)以及會(huì)訊,通過(guò)多渠道互動(dòng)拉近了讀者、作者、審者與本刊間的距離。如您需要查閱當(dāng)期目錄、過(guò)刊、論文檢索、稿件流程、審稿情況和會(huì)訊等,請(qǐng)登錄本刊微信公眾平臺(tái):中國(guó)人獸共患病學(xué)報(bào)(rsghb87552018),下方一欄有“網(wǎng)刊管理”、“稿件管理”及“關(guān)于我們”,相應(yīng)點(diǎn)擊即可查看。感謝編委、審者和廣大作者、讀者們的一貫支持,歡迎通過(guò)平臺(tái)及時(shí)與本刊進(jìn)行互動(dòng)交流。

      Research progress onSalmonellaDerby

      ZHENG Hui-juan, PAN Zhi-ming, JIAO Xin-an

      (JiangsuKeyLaboratoryofZoonosis,JiangsuCo-innovationCenterforPreventionandControlofImportantAnimalInfectiousDiseasesandZoonoses,JiangsuYangzhou,China,JointInternationalResearchLaboratoryofAgricultureandAgri-productSafetyoftheMinistryofEducation,Yangzhou,Jiangsu,China,KeyLaboratoryofPreventionandControlofBiologicalHazardFactors(AnimalOrigin)forAgrifoodSafetyandQuality,MinistryofAgricultureofChina,YangzhouUniversity,Yangzhou, 225009China)

      SalmonellaDerby is recognized as a major human food-borne pathogen causing food poisoning, septicaemia and other symptoms. Meanwhile, it can represent a severe threat to livestock breeding and health. The objective of this review is to summarize novel research progress on epidemic, genomics, pathogenic mechanism ofSalmonellaDerby for provide reference to related research.

      SalmonellaDerby; epidemic; genomics; pathogenic mechanism

      國(guó)家重點(diǎn)研發(fā)計(jì)劃課題(No.2016YFD0501607);公益性行業(yè)(農(nóng)業(yè))科研專項(xiàng)(No.201403054);國(guó)家自然科學(xué)基金(No.31320103907,No.31230070);江蘇省重點(diǎn)研發(fā)項(xiàng)目(No.BE2015343);江蘇省第九批"六大人才高峰"高層次人才項(xiàng)目(No.NY-028);揚(yáng)州大學(xué)科技創(chuàng)新團(tuán)隊(duì);江蘇省高校優(yōu)勢(shì)學(xué)科建設(shè)工程項(xiàng)目聯(lián)合資助

      潘志明,Email:zmpan@yzu.edu.cn

      江蘇省人獸共患病學(xué)重點(diǎn)實(shí)驗(yàn)室/江蘇省動(dòng)物重要疫病與人獸共患病防控協(xié)同創(chuàng)新中心/農(nóng)業(yè)與農(nóng)產(chǎn)品安全國(guó)際合作聯(lián)合實(shí)驗(yàn)室/農(nóng)業(yè)部農(nóng)產(chǎn)品質(zhì)量安全生物性危害因子(動(dòng)物源)控制重點(diǎn)實(shí)驗(yàn)室

      10.3969/j.issn.1002-2694.2017.07.013

      R378.2

      A

      1002-2694(2017)07-0642-04

      2016-04-14 編輯:張智芳

      猜你喜歡
      人獸德?tīng)?/a>沙門
      一株雞白痢沙門菌噬菌體的發(fā)酵及后處理工藝研究
      沙門菌噬菌體溶菌酶LysSHWT1的制備及抑菌活性分析
      Eight O’Clock/by Sara Teasdale八點(diǎn)鐘
      野生動(dòng)物與人獸共患病
      科學(xué)(2020年3期)2020-11-26 08:18:20
      微信素材征集
      2013-2017年北京市順義區(qū)腹瀉病例中沙門菌流行特征
      人獸表演
      人獸共患病的發(fā)生及流行原因分析
      江西省零售畜禽肉中分離的136株沙門菌血清學(xué)鑒定與分析
      寵物
      視野(2009年4期)2009-06-10 12:07:24
      冕宁县| 新邵县| 清河县| 布拖县| 林甸县| 宣汉县| 达州市| 巫溪县| 乌拉特后旗| 钦州市| 富顺县| 泸定县| 修武县| 云梦县| 老河口市| 潜山县| 永州市| 远安县| 淮阳县| 德安县| 临江市| 疏附县| 长岛县| 额济纳旗| 隆安县| 四子王旗| 淳化县| 新乡市| 新乐市| 冀州市| 壤塘县| 崇文区| 南召县| 宽甸| 大余县| 旬阳县| 定远县| 乌什县| 临泉县| 自贡市| 昂仁县|