多學科聯(lián)合治療對肥胖患兒炎癥因子及胰島素抵抗的影響

陳琦　俞碧君　齊茵琳　龐福珍　許光敏

[關鍵詞] 多學科聯(lián)合治療;肥胖癥;炎癥因子;胰島素抵抗

[中圖分類號] R711.75? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）22-0057-05

Effects of multidisciplinary combined therapy on inflammatory factors and insulin resistance in obese children

CHEN Qi1? ?YU Bijun2? ?QI Yinlin1? ?PANG Fuzhen1? ?XU Guangmin1

1.Department of Pediatrics， Tiantai Branch， Zhejiang Provincial People′s Hospital， Tiantai? ?317200， China; 2.International Medical Center （House of Elite Physicians）， Tiantai Branch， Zhejiang Provincial People′s Hospital， Tiantai 317200， China

[Abstract] Objective To investigate the effects of multidisciplinary combined therapy on inflammatory factors and insulin resistance in obese children. Methods A total of 88 obese children who were treated in our hospital from February 2017 to August 2019 were selected as the research objects and divided into the observation group （n=44） and the control group （n=44） according to the random number table method. The control group was treated with conventional therapy， while the observation group was treated with multidisciplinary combined therapy led by the pediatrician. The clinical efficacy， body shape index， inflammatory factors and insulin resistance of the two groups were compared. Results The total effective rate in the observation group was 93.18%， which was higher than that of 77.27% in the control group， with significant difference （P<0.05）. After intervention， BMI， waist-hip ratio and body fat percentage in both groupswere significantly lower than those before intervention，and the decrease in the observation group was higher than that in the control group， with significant difference （P<0.05）; the levels of TNF-α，IL-6 and hs-CRP in the two groups were significantly lower than those before intervention， and the decrease in the observation group was higher than that in the control group， with significant difference （P<0.05）; the levels of FINS，CLU and HOMA-IR in the two groups were significantly lower than those before intervention， and the decrease in the observation group was higher than that in the control group， with significant difference（P<0.05）. Conclusion Compared with conventional therapy， multidisciplinary combined therapy can significantly improve the efficacy of obese children， reduce BMI， waist-hip ratio， body fat percentage and insulin resistance index， and relieve inflammation.