ESAT-6在結(jié)核性腹膜炎中的檢測及其診斷應(yīng)用

饒希 賴玲玲 楊麗霞

[摘要] 目的 研究ESAT-6在結(jié)核性腹膜炎中的檢測及其診斷應(yīng)用價值。 方法 選擇2017年1月至2020年1月我院接診的62例疑似結(jié)核性腹膜炎患者作為本研究對象。按照最終的診斷結(jié)果分為結(jié)核性腹膜炎組50例和腫瘤性腹水組12例。比較兩組患者外周血中ESAT-6的陽性檢出率、腹腔積液中ESAT-6的陽性檢出率;對ESAT-6在結(jié)核性腹膜炎檢測中的敏感度、特異度、陽性預(yù)測率、陰性預(yù)測率、陽性似然比、陰性似然比、約登指數(shù)進(jìn)行比較。 結(jié)果 結(jié)核性腹膜炎組患者外周血中ESAT-6的陽性率明顯高于腫瘤性腹水組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)核性腹膜炎組患者腹腔積液中ESAT-6的陽性率明顯高于腫瘤性腹水組，差異有統(tǒng)計學(xué)意義（P<0.05）。外周血T淋巴細(xì)胞中ESAT-6的敏感度、特異度、陽性預(yù)測率、陰性預(yù)測率、陽性似然比、陰性似然比、約登指數(shù)與腹腔積液T淋巴細(xì)胞中ESAT-6比較，差異無統(tǒng)計學(xué)意義（P>0.05）。 結(jié)論 ESAT-6在結(jié)核性腹膜炎的檢測中有較高的應(yīng)用價值，可以作為評估患者的重要的指標(biāo)。

[關(guān)鍵詞] 結(jié)核性腹膜炎;抗原靶蛋白6;診斷價值;陽性率;敏感度;特異度

[中圖分類號] R526? ? ? ? ? [文獻(xiàn)標(biāo)識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）24-0149-03

Detection and diagnostic application of ESAT-6 in tuberculous peritonitis

RAO Xi? ?LAI Lingling? ?YANG Lixia

Department of Infectious Disease， the First Affiliated Hospital of Nanchang University， Nanchang? ?330006， China

[Abstract] Objective To study the detection and diagnostic application value of ESAT-6 in tuberculous peritonitis. Methods A total of 62 patients with suspected tuberculous peritonitis who were admitted to our hospital from January 2017 to January 2020 were selected as the subjects of this study. According to the final diagnosis results， they were divided into the tuberculous peritonitis group（n=50） and the neoplastic ascites group（n=12）. The positive detection rates of ESAT-6 in peripheral blood and intraperitoneal effusion were compared between the two groups. The sensitivity， specificity， positive prediction rates， negative prediction rates， positive likelihood ratios，negative likelihood ratios and Youden indexes of ESAT-6 in tuberculous peritonitis were compared. Results The positive rate of ESAT-6 in peripheral blood of the tuberculous peritonitis group was significantly higher than that of the neoplastic ascites group， and the difference was statistically significant（P<0.05）. The positive rate of ESAT-6 in peritoneal effusion in the tuberculous peritonitis group was significantly higher than that in the neoplastic ascites group， and the difference was statistically significant（P<0.05）. No statistically significant differences were observed in the sensitivity， specificity， positive prediction rates， negative prediction rates， positive likelihood ratios，negative likelihood ratios and Youden indexes of ESAT-6 between the peripheral blood T lymphocytes and the peritoneal effusion T lymphocytes（P>0.05）. Conclusion ESAT-6 has a high application value in the detection of tuberculous peritonitis， and can be used as an important index to evaluate patients.