陸永霞
【摘要】目的:分析達(dá)格列凈片聯(lián)合鹽酸二甲雙胍片及甘精胰島素注射液預(yù)填充治療老年2型糖尿病的臨床療效。方法:選擇2021年5月—2022年11月期間的86例老年2型糖尿病患者,隨機(jī)分為兩組,分析兩組治療前后血糖水平以及胰島功能指標(biāo)。結(jié)果:治療后,觀察組FPG、2h PG、HbAlc水平均明顯低于對照組,觀察組HOMA-IR水平明顯低于對照組,觀察組HOMA-IS水平明顯高于對照組(P<0.05)。結(jié)論:針對2型糖尿病患者采用達(dá)格列凈片聯(lián)合鹽酸二甲雙胍片以及甘精胰島素注射液預(yù)填充治療,效果理想,值得廣泛應(yīng)用及推廣。
【關(guān)鍵詞】達(dá)格列凈片;鹽酸二甲雙胍片;甘精胰島素注射液預(yù)填充;老年2型糖尿病
Clinical observation of Dagliegine tablets combined with metformin hydrochloride tablets and insulin glargine injection in the treatment of senile type 2 diabetes mellitus
LU Yongxia
The First Peoples Hospital of Yuzhong County, Gansu Province, Lanzhou, Gansu 730100, China
【Abstract】Objective: To analyze the clinical efficacy of Dagliegine tablets combined with metformin hydrochloride tablets and insulin glargine injection in the treatment of senile type 2 diabetes mellitus. Methods: A total of 86 elderly patients with type 2 diabetes mellitus from May 2021 to November 2022 were randomly divided into two groups to analyze blood glucose levels and islet function indexes before and after treatment. Results: After treatment, FPG, 2h PG and HbAlc levels in the observation group were significantly lower than those in the control group, HOMA-IR level in the observation group was significantly lower than that in the control group, and HOMA-IS level in the observation group was significantly higher than that in the control group(P<0.05). Conclusion: For patients with type 2 diabetes mellitus, Dagliegine tablets combined with metformin hydrochloride tablets and insulin glargine injection for prefilling treatment, the effect is ideal, worthy of wide application and promotion.
【Key Words】Dagliegine tablet; Metformin hydrochloride tablets; Insulin glargine injection prefilling; Elderly type 2 diabetes mellitus
作為糖尿病的類型之一,2型糖尿病相對來說比較常見,也可以被稱為成人發(fā)病型糖尿病,究其原因,主要是成年人群體更容易引發(fā)該病癥[1]。2型糖尿病的病因較多,而且具有一定的復(fù)雜性,會對患者體內(nèi)的胰島素分泌產(chǎn)生影響,使其產(chǎn)生胰島素分泌不足的現(xiàn)象,或?qū)е绿悄虿』颊叱霈F(xiàn)胰島素抵抗、胰島素絕對缺乏等相關(guān)問題,進(jìn)而使患者的血糖水平呈現(xiàn)不斷升高的趨勢[2]。當(dāng)老年患者長時(shí)間處于高血糖的環(huán)境之中,勢必會對身體產(chǎn)生不同程度的影響,無論是大血管,還是微血管,又或者是神經(jīng)系統(tǒng),都會因此產(chǎn)生一定病變,進(jìn)而對其多處器官產(chǎn)生損害,威脅患者生命健康。針對這一常見病,及時(shí)治療是關(guān)鍵[3]。通過藥物治療的方式,主要是對患者的血糖水平進(jìn)行控制,目前比較常用的藥物有鹽酸二甲雙胍片等,而單一用藥的效果不盡人意,需要不斷深入研究和探索更為有效的藥物治療方案,通過選擇合適藥物進(jìn)行聯(lián)用,產(chǎn)生更好的降糖效果。鑒于此,文章主要探討達(dá)格列凈片聯(lián)合鹽酸二甲雙胍片及甘精胰島素注射液預(yù)填充治療老年2型糖尿病患者的臨床療效分析,現(xiàn)將本文作以下匯報(bào)。
1.1 一般資料
選擇我院2021年5月—2022年11月期間的86例老年2型糖尿病患者,隨機(jī)分為兩組。對照組,年齡52~80歲,平均年齡(65.22±3.45)歲;觀察組,年齡51~82歲,平均年齡(65.43±3.21)歲。一般資料對比,P>0.05,無統(tǒng)計(jì)學(xué)差異。
1.2 方法