吳堅平 楊立榮
摘 要:生物制造手性化學(xué)品是以生物學(xué)、化學(xué)、工程學(xué)及信息學(xué)等學(xué)科的交叉為手段,以光學(xué)純化學(xué)品的高質(zhì)量合成為目標(biāo),以快速、高效、高選擇性和綠色為特征,以蛋白結(jié)構(gòu)分析、分子生物學(xué)、合成生物學(xué)、化學(xué)合成和反應(yīng)工程學(xué)及系統(tǒng)工程理論等為手段,為手性化學(xué)品的清潔、高效、經(jīng)濟(jì)和快速生產(chǎn)提供創(chuàng)造性設(shè)計思想和新型科學(xué)方法。通過分子理性設(shè)計、反應(yīng)性能強(qiáng)化和制造系統(tǒng)重構(gòu),最終實現(xiàn)手性化學(xué)品的高效綠色生物制造。
關(guān)鍵詞:生物制造 手性化學(xué)品 理性設(shè)計 性能強(qiáng)化 系統(tǒng)重構(gòu) 綠色制造 高效
Abstract:Bio-manufacturing of chiral chemicals uses the cross means of biology, chemistry, engineering and informatics. It focuses on the high quality synthesis of optical pure chemicals, in a quick, efficient, high selective and green way. Based on the analysis of protein structure, molecular biology, synthetic biology, chemical synthesis, reaction engineering and system engineering, it provides creative design thinkings and new scientific methods for the clean, efficient, economic and fast production of chiral chemicals. Through rational design, reaction performance enhancement and reconstruction of manufacturing systems, the efficiency green-manufacturing of chiral chemicals will be realized.
Key Words:Bio-manufacturing;Chiral chemicals;Rational design;Performance enhancement;System reconstruction;Green-manufacturing;High efficiency
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